Functional reconstitution of NKT cells in HIV-1 infected individuals

submitted by: dzhoumda
A reduction in the generation of lung-homing TB-specific effector memory CD4 Th1 cells after HIV infection is a key factor in the increased risk of active TB disease. Natural killer T cells are an innate type of immune cells responsible for first line of anti-viral defense, which may “jump-start” the adaptive immune responses and regulate the Th1 versus Th2 differentiation of CD4 helper T cells, through their unique ability to activate antigen-presenting cells (e.g., DCs). The regulatory...

Projected effects of tobacco smoking on worldwide tuberculosis control: mathematical modelling analysis

submitted by: ucsfnews
BMJ 2011; 343:d5506 http://bmj.com/cgi/content/full/bmj.d5506 http://www.ncbi.nlm.nih.gov/pubmed/21972295 ABSTRACT We constructed a state transition, compartmental, mathematical model of tuberculosis epidemics to estimate the impact of alternative future smoking trends on tuberculosis control. We projected tuberculosis incidence, prevalence, and mortality in each World Health Organization region from 2010 to 2050, and incorporated changing trends in smoking, case detection,...

History of TB

submitted by: bccdc

A video describing the hisotry of Tuberculosis.

Tuberculin Skin Test for Aboriginal Communities

submitted by: bccdc

Describes how the TB Skin test works.

TB Programming in BC

submitted by: bccdc

Describes how the TB program for British Columbia is implemented including screening, treatment, testing and locations around the province.

The BCG World Atlas

submitted by: azwerling
Despite nearly a century of use, the BCG vaccine continues to be controversial, with known variations in BCG substrains and vaccine efficacy. Because vaccination policies and practices have varied substantially across time and countries, we created this first searchable, online database of global BCG vaccination policy and practices. This interactive website provides detailed information on current and past BCG policies and practices for over 180 countries. The Atlas is designed to be a...

What is TB? (not TV)

submitted by: bccdc

In this BCCDC produced video children from John Filed Elementary School use posters to explain what they have learned about Tuberculosis (TB) infection and disease and how it can be cured. Gitxsan elders discuss their experience with Tuberculosis in the days of the Sanatoria.

Effective Business Strategies In The Battle Against TB

submitted by: YourUpdateTV

Top multinational business and nonprofit leaders met in New York to discuss the role of the private sector in curbing the spread of tuberculosis. Video source: BD.

Tuberculosis: A Persistent Threat to Global Health - Part 4: Targeting M. tuberculosis Carbon Metabolism In Vivo (26:12)

submitted by: video_collector
All pathogens must acquire and assimilate nutrients from their hosts in order to grow and multiply -- our tissues are literally their food -- yet surprisingly little is known about this fundamental aspect of the pathogenic lifestyle. Accumulating evidence suggests that M. tuberculosis might utilize fatty acids as its principal carbon and energy source during infection. The fourth part of this lecture describes work in our laboratory that is focused on identifying the metabolic pathways that...

Tuberculosis: A Persistent Threat to Global Health - Part 3: Phenotypic Heterogeneity and Antibiotic Tolerance (27:15)

submitted by: video_collector
The principal obstacle to successful treatment of tuberculosis is the lengthy duration of current regimens, which require administration of multiple drugs for 6-9 months. The requirement for prolonged therapy is attributed to sub-populations of bacillary "persisters" that are refractory to antimicrobials. The persisters are not drug-resistant in the conventional (heritable) sense and it is a mystery why they are spared whilst their genetically identical siblings are killed. The third part of...