Tree of Life

submitted by: Treeoflife
Explore the evolutionary links between living things with the Wellcome Trust's Tree of Life, developed as part of our Darwin 200 activities, which celebrate the 200th anniversary of Charles Darwin's birth. This six-minute Tree of Life video also appeared on the BBC One programme 'Charles Darwin and the Tree of Life' narrated by David Attenborough. In addition to the video, an interactive version of the 'Tree of Life' here ( http://www.wellcometreeoflife.org ) has been created to allow...

Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

submitted by: JCB
The establishment of apical–basal polarity within a single cell and throughout a growing tissue is a key feature of epithelial morphogenesis. To examine the underlying mechanisms, the human intestinal epithelial cell line Caco-2 was grown in a three-dimensional matrix to generate a cystlike structure, where the apical surface of each epithelial cell faces a fluid-filled central lumen. A discrete apical domain is established as early as the first cell division and between the two daughter...
Authors: Aron Jaffe, Noriko Kaji, Joanne Durgan, Alan Hall

One-Dimensional Topography Underlies Three-Dimensional Fibrillar Cell Migration

submitted by: JCB
Current concepts of cell migration were established in regular two-dimensional (2D) cell culture, but the roles of topography are poorly understood for cells migrating in an oriented 3D fibrillar extracellular matrix (ECM). We use a novel micropatterning technique termed microphotopatterning (µPP) to identify functions for 1D fibrillar patterns in 3D cell migration. In striking contrast to 2D, cell migration in both 1D and 3D is rapid, uniaxial, independent of ECM ligand density, and...
Authors: Andrew Doyle, Francis Wang, Kazue Matsumoto

Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge

submitted by: JCB
Chemoattractant signaling induces the polarization and directed movement of cells secondary to the activation of multiple effector pathways. In addition, chemotactic signals can be amplified and relayed to proximal cells via the synthesis and secretion of additional chemoattractant. The mechanisms underlying such remarkable features remain ill defined. We show that the asymmetrical distribution of adenylyl cyclase (ACA) at the back of Dictyostelium discoideum cells, an essential determinant...
Authors: Paul Kriebel, Valarie Barr, Erin Rericha, Guofeng Zhang, Carole Parent

The Interview

submitted by: vanderploegt

As the only member of the new Hybrid class of multi-mode microplate readers, Synergy 4 is sure to impress the lab with his combination of fluorescent-based technologies. But who else is peeking in on the interview?

Check it out!

Plant biotech for food and environment

submitted by: pieter

A better knowledge ot the processes in plants can lead to plants that are better suited for food and environment.

Biotech for Health

submitted by: pieter

Fundamental biomedical research leads to hope against 'incurable' diseases, like ALS, cancer and Chron's

ALS

submitted by: pieter

Research at VIB comes closer to a solution for ALS

E-Cell simulation environment 3D: 3D visualization of cell simulation

submitted by: gaou

E-Cell Simulation Environment 3D allows 3D visualization of cell simulation experiments for systems biology studies, powered by Quartz Composer in MacOS X(Tiger). BGM is "She's Close" by The Lingus (available in creative commons license). Developed by the Institute for Advanced Biosciences, Keio University, Japan.

An Iconography of Contagion - MWV24

submitted by: MicrobeWorld
In this episode of MicrobeWorld Video we visit the National Academy of Sciences in Washington, D.C., for the opening of "An Iconography of Contagion," an art exhibition featuring more than 20 public health posters from the 1920s to the 1990s. Covering infectious diseases such as malaria, tuberculosis, AIDS, gonorrhea, and syphilis, the posters come from North America, Europe, Asia, and Africa. This video features interviews with J.D. Talasek, Director of Cultural Programs of the National...