Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates UV induced melanocyte homeostasis

submitted by: arup.indra
Keratinocytes contribute to melanocyte activity by influencing their microenvironment, in part, through secretion of paracrine factors. Here we discovered that p53 directly regulates Edn1 expression in epidermal keratinocytes and controls UV-induced melanocyte homeostasis. Selective ablation of EDN1 in murine epidermis (EDN1ep-/-) does not alter melanocyte homeostasis in newborn skin but decreases dermal melanocytes in adult skin. Results showed that keratinocytic EDN1 in a non-cell...
Authors: Daniel J. Coleman, Gitali Ganguli-Indra, Stephen Hyter, Arup Indra, Steven Ma, Gary F. Merrill, Masashi Yanagisawa

Identification and Regulation of c-Myb Target Genes in MCF-7 cells.

submitted by: aquintan
BACKGROUND: The c-Myb transcription factor regulates differentiation and proliferation in hematopoietic cells, stem cells and epithelial cells. Although oncogenic versions of c-Myb were first associated with leukemias, over expression or rearrangement of the c-myb gene is common in several types of solid tumors, including breast cancers. Expression of the c-myb gene in human breast cancer cells is dependent on estrogen stimulation, but little is known about the activities of the c-Myb...
Authors: Anita m. Quintana, Fan Liu, John p. O'rourke, Scott a. Ness

Time-resolved monitoring of the transcriptome of MCF-7 breast cancer cells during the emergence of cisplatin resistance

submitted by: martin_unibonn

Gene expression measurement during treatment with Cisplatin for breast cancer.

Gene Expression Computational Lab - Chris Miller

submitted by: ralanharris

An introduction to computational methods for analyzing gene expression data by Chris Miller. This was presented as a lab within the Computer Aided Discovery Methods course offered within the Graduate Program at Baylor College of Medicine.

The genetic response to Snowball Earth: role of HSP90 in the Cambrian explosion

submitted by: Michael Baker
"The Genetic Response to Snowball Earth: Role of HSP90 in the Cambrian Explosion" Download this paper at the following web address: http://repositories.cdlib.org/postprints/2103 The events that shaped the Cambrian explosion from 545 to 530 Ma, when multicellular animals suddenly appeared in the fossil record, are not fully understood. It is likely that the evolution of new transcription factors and other signal transduction proteins that regulated developmental networks was important...
Authors: M. e. Baker

Small Regulatory RNAs May Sharpen Spatial Expression Patterns

linked profile(s): hlevine
submitted by: apryl
The precise establishment of gene expression patterns is a crucial step in development. Formation of a sharp boundary between high and low spatial expression domains requires a genetic mechanism that exhibits sensitivity, yet is robust to fluctuations, a demand that may not be easily achieved by morphogens alone. Recently, it has been demonstrated that small RNAs (and, in particular, microRNAs) play many roles in embryonic development. Whereas some RNAs are essential for embryogenesis,...
Authors: Erel Levine, Peter Mchale, Herbert Levine