Organs on a chip

submitted by: nsf

Organs on a chip systems could transform the medical drug pipeline as we know it. Biomedical engineer Ali Khademhosseini explains how he and his team at MIT are engineering tissues outside of the human body and connecting different "organs" to solve some pressing challenges.

Mechanics of Tissue Growth

submitted by: icamvid

Mechanics of Tissue Growth by Jacques Prost, ESPCI, Paris, France
Soft Active Materials
May 18, 2009 – May 21, 2009
Syracuse University, New York

Role of the Neural Crest in Vertebrate Development and Evolution - Part 2: The Role of the Neural Crest in Head Development and in Vertebrate Evolution (30:04)

submitted by: video_collector
Nicole Le Douarin shares her research on the role of the neural crest in skeletal development. The Q/C (quail/chick) marker system revealed that apart from the peripheral nervous system (PNS), the melanocytes and some endocrine tissues, the NC plays a major role in the construction of the vertebrate head. The entire facial skeleton and part of the skull (frontal, squamosal, parietal bones) are of NC origin together with the connective tissues of the face and ventral part of the neck. The...

Cytokines and Neutrophins in Neuroprotection

submitted by: alex01
Dr. Michael Spedding published recently a review on the role of cytokines and neurotrophins in disease. Neurotrophins (e.g. BDNF) have beneficial effects on neuronal plasticity and brain metabolism. Inflammatory cytokines (e.g. IL1beta)oppose the effects of neurotrophins. Both, neurotrophins and cytokines are targets for the development of new drugs affecting central nervous system. Brain-derived neurotrophic factor (BDNF) is the main activity-dependent neurotrophic factor. Interleukin 1beta...

AMPA Ligands in Neuroprotection

submitted by: alex01
Michael Spedding (Institute Internatinales Servier, Paris, France) described how neuroprotection can be achieved by either by blockade or by stimulation of AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors. Low threshold AMPA receptor stimulation leads to the release of BDNF (brain-derived neurotrophic factor) which is neuroprotective. Blockade of AMPA receptors reduces excitotoxicity leading to neuroprotection. BDNF is a major activity-dependent neurotrophic factor...

Tumour cords' growth in a vascular network

submitted by: sast
Evolutions of oxygen concentration and formation of hypoxic zones during tumour growth in the vascular network . This simulation was produced with an experimental modification to the model, where vessels are oxygen sources inside the simulation domain, cells do not switch to anaerobic metabolism in this simulation. For more information refer to .

ATP deficit in oxygen-limited tumour cord growth (FF++)

submitted by: sast
This is a simulation of tumour cord growth , where cells suffer from hypoxia (energy deficit shown with colour). The tumour grows along the blood vessel (coincides with x -axis). Red line shows the position of the tumour–host interface. This particular simulation was programmed in FreeFEM++ out of curiousity. The source code for simulation may be found at . This video reflects work in progress and may be different from the final results .

Tissue movement in bipopulation tumour cord growth

submitted by: sast

Simulation of tumour cord growth where conversion of the tumour to glycolytic (anaerobic) metabolism takes place under hypoxia. This video shows volume fraction of glycolytic cell population and velocity of tissue movement. Isolines show hypoxia limits for aerobic and anaerobic cell lines respectively. This video reflects work in progress and may be different from the final results.

Biology of Plants

submitted by: scivee-team

An overview of the process of photosynthesis and the biology of plants - function, reproduction and life.

Biology of Algae

submitted by: scivee-team

An overview of the biology of algae and microorganisms.