Lactobacillus rhamnosus GG and Bifidobacterium animalis MB5 Induce Intestinal but Not Systemic Antigen-Specific Hyporesponsiveness in Ovalbumin-Immunized Rats

submitted by: mengheri
Probiotics may modulate the host immune response by mechanisms not yet fully understood. We evaluated the modulation of intestinal and systemic antigen-specific immune response by Lactobacillus rhamnosus GG (LGG) or Bifidobacterium animalis MB5 in tolerized and immunized rats. Three groups of rats received orally LGG, B. animalis, or PBS (control) for 28 d. Each group was divided into two subgroups of tolerized or immunized rats receiving orally ovalbumin (OVA; 7 mg) or PBS on d 7, 9, and...
Authors: Alberto Finamore, Marianna Roselli, Maria Serena Britti, Nicolò Merendino, Elena Mengheri

The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase

submitted by: tracyanthony
Amino acid starvation by asparaginase (ASNase) enhances phosphorylation of eIF2 by general control nonderepressible 2 (GCN2) kinase, leading to reduced global mRNA translation rates. This conserves energy and allows cells time to reprogram stress-related gene expression to alleviate cell injury. This study addressed the importance of GCN2 for the immune system to adapt to amino acid starvation by ASNase. GCN2+/+ and GCN2-/- mice were injected once daily with ASNase or saline for up to 7 d....
Authors: Carla Aldrich, Ronald Wek, Rachel Reinert, Judy Cundiff, Piyawan Bunpo, Tracy Anthony

Therapies for Multiple Sclerosis

submitted by: alex01

J. Kocsis, PhD. - The current approaches to the therapy of multiple sclerosis are reviewed by J. Kocsis (Yale University). His research emphasizes remyelination as an approach to the therapy of multiple sclerosis and spinal cord injury.