Breast Cancer Coalition talk on Open Notebook Science

submitted by: jcbradley
Jean-Claude Bradley presents "Accelerating Discovery by Sharing: a case for Open Notebook Science" on May 1, 2011 at the National Breast Cancer Coalition Annual Advocacy Conference in Arlington, VA. First a few examples are provided which show how a lack of transparency in science can retard progress by creating ambiguity. Demonstrations of the use of Open Notebook Science in malaria research, solubility and other chemistry related applications then follow. Examples of web services...

Microtubules Keep Tumor Cells Breathing Easy

submitted by: JCB
The transcription factor HIF-1α is essential for a cell's response to low oxygen conditions. Carbonaro et al. demonstrate that production of HIF-1α protein is regulated by dynamic microtubules and that microtubule-targeting drugs shift HIF-1α mRNA into cytoplasmic P-bodies, where its translation is repressed by miRNAs. This biosights episode presents the paper by Carbonaro et al. from the January 10, 2011, issue of The Journal of Cell Biology, and includes an interview with authors Marisa...

Long Asters Rock The Spindle

submitted by: JCB
Astral microtubules help position the cytokinetic furrow by confining actomyosin contractility to the cell equator. Rankin and Wordeman reveal that if astral microtubules grow too long, they expand membrane blebs at the mitotic cell poles that squeeze the mitotic spindle back and forth between the two daughter cells. This biosights episode presents the paper by Rankin and Wordeman from the July 12, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Linda...