Immunotherapy: unleashing immune system to attack cancer

submitted by: mdanderson
Cancer immunotherapy treats the immune system rather than the tumor. Jim Allison, Ph.D., professor in Immunology at MD Anderson Cancer Center, has developed an innovative approach that will open doors for treating all types of cancer. Padmanee Sharma, M.D., Ph.D., associate professor in Genitourinary Medical Oncology and Immunology, is lead scientist on immunotherapy clinical trials. Listen to Allison and Sharma discuss their collaboration on MD Anderson’s Moon Shots Program to develop...

New solution for therapeutic cancer vaccine failure

submitted by: mdanderson
http://www.mdanderson.org/newsroom/news-releases/2013/cancer-vaccines-ch... Vaccines designed to turn the immune system against cancer have been logically constructed and tested against many cancers. Almost all have failed or shown minimal effect. They spark creation of killer T cells against the cancer, but generally have little effect on tumors, both in patients and mouse models. Willem Overwijk, Ph.D., and colleagues at MD Anderson discovered that a common vaccine component is...

CKIδ Decentralizes the Centrosome

submitted by: JCB
When a T cell encounters a target antigen-presenting cell, the lymphocyte's centrosome relocalizes to a specialized contact between the two cells called the immunological synapse. Zyss et al. reveal that casein kinase Iδ helps to reposition the centrosome in activated T cells, perhaps by working with the microtubule plus-end binding protein EB1 to regulate microtubule growth. This biosights episode presents the paper by Zyss et al. from the November 28, 2011, issue of The Journal of Cell...

T Cells Rho across the endothelium

submitted by: JCB
During an immune response, T cells move into tissues from the vasculature by crossing the endothelial cell layer lining blood vessel walls. Heasman et al. reveal that this transendothelial migration requires signaling at both the front and back of leukocytes by the small GTPase RhoA. This biosights episode presents the paper by Heasman et al. from the August 23, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Anne Ridley. Produced by Caitlin Sedwick...