Background: We recently reported that the elevated blood pressure
(BP) observed in patients with cardiovascular disease who are homozygous
for the 677C/T polymorphism (TT genotype) in the gene
encoding methylenetetrahydrofolate reductase (MTHFR) was responsive
to supplementation with riboflavin—the cofactor for MTHFR.
Objective: The objective was to investigate the effect of riboflavin
on BP targeted at patients with the TT genotype 4 y after initial
Authors: Carol P Wilson, Mary Ward, Helene McNulty, J J Strain, Tom G Trouton, Geraldine Horigan, John Purvis, John M Scott