DFG motif: A Protonation Dependent Conformational Switch

submitted by: icamvid

Yibing Shan gives a talk at the RPP08 conference about the mechanism of DFG flip in Abl kinase:
1) Simulation of DFG flip
2) An energetic model: the role of protonation
3) Experimental test
4) What's the DFG flip for?

Free Energy Landscape, Conformational Changes and the Transduction of Biological Signals

submitted by: icamvid

Benoit Roux gives a talk at the RPP08 conference about free energy landscape, conformational changes and the transduction of biological signals. He also talks about the multiscale approaches to the activation, inactivation of Src kinases.

Electrostatics and long-range coupling in Src kinase activation

submitted by: icamvid

Carol Post gives a talk at the RPP08 conference on Src, a mechanism of conformational activation. She covers two topics regarding it Src:
1) Switched electrostatic network
2) long-range coupling of regulatory SH2/SH3 and catalytic domain

Gene Expression Computational Lab - Chris Miller

submitted by: ralanharris

An introduction to computational methods for analyzing gene expression data by Chris Miller. This was presented as a lab within the Computer Aided Discovery Methods course offered within the Graduate Program at Baylor College of Medicine.