The Spindle's Model Behavior

submitted by: JCB
Dynamic microtubules assemble into a steady state bipolar spindle structure but precisely how this is achieved is unclear. Loughlin et al. develop a computational model that predicts how a few key activities organize microtubules in Xenopus meiotic spindles. This biosights episode presents the paper by Loughlin et al. from the December 27, 2010 issue of The Journal of Cell Biology, and includes an interview with author François Nédélec (EMBL, Heidelberg, Germany). Produced by Caitlin...

Probing the spindle matrix

submitted by: JCB
A microtubule-independent network of proteins called the spindle matrix is involved in assembling mitotic and meiotic spindles, but whether the matrix makes a mechanical contribution to spindle shape is unclear. Gatlin et al. manipulate spindles with microneedles to directly probe the mechanical properties of the spindle matrix. This biosights episode presents the paper by Gatlin et al. from the February 22, 2010 issue of The Journal of Cell Biology, and includes an interview with lead...