Laminin Adhesions Help Microtubules Reach Base

submitted by: JCB
Microtubules align along the apical-basal axis of epithelial cells with their plus ends pointing to the basal side. Hotta et al. reveal how signals from the extracellular matrix establish this arrangement by recruiting the microtubule-anchoring factors LL5s to the basal cell cortex. This biosights episode presents the paper by Hotta et al. from the May 31, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Yuko Mimori-Kiyosue. Produced by Caitlin...

Adhesion, Signaling and Cancer: Part 3: Focal Adhesions as Stress Sensors (30:57)

submitted by: scivee-team
In the third segment of my seminar, I address a new frontier in cell biology, that is how cells respond to mechanical information. Cells and tissues are exposed to physical forces in vivo and excessive mechanical stress leads to a variety of pathological consequences. I describe a system for exposing cells to controlled mechanical stress and discuss the stretch response. We have discovered that the focal adhesion protein, zyxin, is exquisitely sensitive to mechanical stimulation and is...

Adhesion, Signaling and Cancer: Part 2: Discovery and Characterization of a Focal Adhesion Protein Implicated in Tumor Progression (50:54)

submitted by: scivee-team

In the second segment, I describe the identification of the focal adhesion protein, zyxin, by my lab. Recent work revealed that zyxin is down-regulated upon expression of the Ewing sarcoma oncoprotein, EWS-FLI. Loss of zyxin expression results in enhanced cell motility and is also associated with failed apoptotic signaling. Evidence that zyxin shuttles between focal adhesions and the nucleus is presented. The impact of reduced zyxin expression on tumor progression is discussed.

It’s easy to get lost on the biological superhighway. Thankfully, we brought a map.

submitted by: dabraham
Biological annotations and terms have gotten a makeover with RGD’s interactive pathway diagrams. The Rat Genome Database makes biological pathways and their components easy to navigate and analyze through this newly added diagrams feature at http://rgd.mcw.edu/wg/pathway?100 . This video will show you how to easily access, view, and gather information from these diagrams and all the great tools they offer. See our RGD website at http://rgd.mcw.edu for more information and tools for...