Urinary a-carboxyethyl hydroxychroman can be used as a predictor of a-tocopherol adequacy, as demonstrated in the Energetics Study

submitted by: mtraber
Background: Other than the in vitro erythrocyte hemolysis test, no valid biomarkers of vitamin E status currently exist. Objective: We hypothesized that the urinary vitamin E metabolite a-carboxyethyl hydroxychroman (a-CEHC) could serve as a biomarker. Design: The relations between urinary a-CEHC, plasma a-tocopherol, and vitamin E intakes were assessed by using a previously validated multipass, Web-based, 24-h self-administered dietary recall, and we concurrently collected plasma and...
Authors: Katie M Lebold, Alfonso Ang, Maret G Traber, Lenore Arab

Retinol May Counteract the Negative Effect of Cadmium on Bone

submitted by: agnake
Cadmium and high vitamin A intake are both proposed risk factors for low bone mineral density (BMD), but potential interactions have not been studied. Within the Women’s Health in the Lund Area, a population-based study in southern Sweden,wemeasured retinol in serumamong 606womenaged 54–64 y. Data onBMDwere measured byDXAat the distal forearm. Parathyroid hormone (PTH), bone alkaline phosphatase (bALP), and osteocalcin in serum and deoxypyridinoline (DPD) and cadmium in urine were...
Authors: Thomas Lundh, Jonas Lidfeldt, Per Bjellerup, Staffan Skerfving, Helen Håkansson, Annette Engström, Göran Samsioe, Marie Vahter, Agneta Åkesson

Rabbit Models for Alzheimer's Disease

submitted by: alex01

Diana Woodruff-Pak (Temple University, Philadelphia, PA) used cholesterol-fed rabbits as a model of AD for evaluation of currently available and potential anti-Alzheimer drugs. These animals developed typical Alzheimer pathology, including behavioral changes and deposition of ß-amyloid and even
tau. Galantamine and donepezil partially protected animals from Alzheimer symptomatology.

Louis Flamand (Diagnostic Assays Session)

submitted by: hhv-6foundation

"Multicenter comparison of PCR assays for the detection of human herpesvirus-6 DNA in serum"
6th International Conference on HHV-6 & 7 in Baltimore, Maryland, USA
Day 1 - June 20, 2008 - Diagnostic Assays Session