"Population Genomics and the Bacterial Species Concept"- Peg Riley @ '09 DOE JGI User Meeting

submitted by: JGI

Peg Riley, (U. Massachusetts) presentation for DOE JGI '09 User Meeting on March 27, 2009, introduction by Eddy Rubin (JGI).

"Development of Cellulosic Biofuels"- Chris Somerville @ '09 DOE JGI User Meeting

submitted by: JGI

Chris Somerville (Energy Biosciences Institute) keynote talk for DOE JGI '09 User Meeting on March 25, 2009, introduction by Jim Bristow (JGI).

"Reading and Writing the Genetic Code"- Craig Venter @ '09 DOE JGI User Meeting

submitted by: JGI

Craig Venter (JCVI) keynote talk for DOE JGI '09 User Meeting on March 27, 2009.

The Biology of Genomes (2008) with David Bentley Interviewed by Chris Gunter

Dr. David Bentley is Vice President and Chief Scientist at Illumina Inc, developing new DNA sequencing technology for fast, accurate sequencing of complex genomes. His major research interest is the study of human sequence variation. He was previously Head of Human Genetics and founding Member of the Board of Management at the Wellcome Trust Sanger Institute, where he played leading roles in the Institute's contribution the human genome reference sequence, The SNP Consortium and the...

The Biology of Genomes (2008) with Michael Ashburner Interviewed by Orli Bahcall

Michael Ashburner (1942-) is Professor of Biology at the University of Cambridge and is the former Joint-Head of the European Bioinformatics Institute (EBI).He was educated at the Royal Grammar School, High Wycombe and the University of Cambridge, where he received his undergraduate degree (1964) and Ph.D. (1968), both in genetics. He then went to the California Institute of Technology as a postdoctoral fellow with Hershell Mitchell. In 1979, he returned to the Department of Genetics in...

"Reading & Writing Genomes" - George Church @ '09 DOE JGI User Meeting

submitted by: JGI
George Church (Harvard University) keynote talk for DOE Joint Genome Institute (JGI) '09 Church elaborates on the future direction and development of genomic sequensing and reducing the cost of genomic research, while increasing the efficiency and possibilities, inclusive of developing multivirus resistance genomes. User Meeting on March 26, 2009, with introduction by Len Pennacchio (JGI).George Church (Harvard University) keynote talk for DOE JGI '09 User Meeting on March 26, 2009, with...

Single molecule analyses of DNA in environmental microbes

submitted by: dougramsey
Comprehensive characterization of genomic composition in environmental microbial samples has been challenging, because the majority of microorganisms are difficult to culture. Additional challenges include a high degree of genetic diversity between and within species, various level of relative abundance and ubiquitous presence of cell-free DNA. Single cells or single molecules genomic assays hold great promise for tackling these challenges. Recent progresses in the developments of these...

International Soil Metagenome - Sequencing Project

submitted by: dougramsey
Soil is often considered to be one of the main reservoirs of microbial diversity on the planet. This diversity could provide a range of information about the origins of microbial functional diversity as well as novel genetic resources. However, our historical inability to cultivate the majority of soil bacteria has hampered our understanding and exploitation of this large diverse community (more than 95% are often considered inaccessible through traditional culture techniques). Over the last...

Challenges in Ecological Metagenomics

submitted by: dougramsey
Since the first metagenomics study was published 17 years ago, the ability to make ecological inferences has been limited by sequencing throughput and the ability to analyze the data. Yet, if the potential of metagenomics to help us decipher the structure and function of microbial ecosystems is to be realized, it is essential that our bioinformatics tools motivate our sequencing efforts. This is analogous to the bioinformatics advances that were made to accelerating the sequencing of the...

Efficient Metagenomics Data Processing: Pitfalls and Solutions

submitted by: dougramsey
Nikos Kyrpides, Joint Genome Institute Co-authors: Kostas Mavrommatis, Natalia Ivanova Metagenomics has emerged as a powerful tool for exploration of the functional capabilities of microbial communities regardless of the ability of their members to grow in pure culture. However, little is known for the efficacy of the methods used to process these datasets. Further more, sequencing of environmental genomic DNA usually results in large, highly fragmented datasets representing a significant...