Dietary Selenium Deficiency Partially Rescues Type 2 Diabetes–Like Phenotypes of Glutathione Peroxidase-1–Overexpressing Male Mice

submitted by: xlei
This study was conducted to determine whether dietary Se deficiency precluded overproduction of glutathione peroxidase-1 (GPX1) activity in mice overexpressing (OE) this gene and thus rescued their type 2 diabetes–like phenotypes. A total of 20 male OE and wild-type (WT) mice were fed an Se-deficient (<0.02 mg/kg) diet or an Se-supplemented (0.3 mg/kg as sodium selenite) diet from 1 to 5 mo of age. Dietary Se deficiency eliminated or attenuated (P < 0.05) genotype differences in...
Authors: Xin Gen Lei, Li Li, Matt Pepper, Carol Roneker, Marko Vatamaniuk, Xi Yan

Prolonged Dietary Selenium Deficiency or Excess Does Not Globally Affect Selenoprotein Gene Expression and/or Protein Production in Various Tissues of Pigs

submitted by: leilab
We previously determined the effects of dietary selenium (Se) de?ciency or excess on mRNA abundance of 12 selenoprotein genes in pig tissues. In this study, we determined the effect of dietary Se on mRNA levels of the remaining porcine selenoprotein genes along with protein production of 4 selenoproteins (Gpx1, Sepp1, Selh, and Sels) and body glucose homeostasis. Weanling male pigs (n = 24) were fed a Se-de?cient (,0.02 mg Se/kg), basal diet supplemented with 0, 0.3, or 3.0 mg Se/kg as...
Authors: Yan Liu, Hua Zhao, Qiaoshan Zhang, Jiayong Tang, Ke Li, Xin-Jie Xia, Kang-Ning Wang, Kui Li, Xin Gen Lei

Selenium, Finasteride and Other Prostate Health Supplements

submitted by: mdanderson

Please visit: www.mdanderson.org/prevention for more information regarding prevention and screening.Get the facts on selenium, finasteride and other supplements believed to prevent prostate cancer.