Schizophrenia

The assessment of iron status where infections are common is complicated by the effects of inflammation on iron indicators and in this study we compared approaches that adjust for this influence. Blood was collected in 680 children (aged 6–35 mo) and indicators of iron status [(hemoglobin (Hb), zinc protoporphyrin (ZP), ferritin, transferrin receptor (TfR), and TfR/ferritin index)] and subclinical inflammation [(the acute phase proteins (APP) C-reactive protein (CRP), and a-1-acid...

Decoding the Riddle of Mental Illness through an overall communicational dynamic. The communicational factors underlying mental illness remain one of mankind's most enduring mysteries. Mental illness is primarily regarded as a physical disorder or a chemical imbalance, although clear-cut signs within the brain have eluded convincing documentation. Indeed, the most obvious outward signpost is a disturbance in the ability to communicate in an interpersonal sense, often in an exaggerated or...

Dr. Ali Zirakzadeh, Consultant in General Internal Medicine at Mayo Clinic in Rochester, MN, discusses his article on various disorders associated with sexual abuse and the most violent form of abuse, rape, in men and women.

Gregory Rose from PharmExperts.com interviews J. Buccafusco (Medical College of Georgia, Augusta, GA) about his development of new anti-Altzheimer drugs, designed to act by multiple mechanisms to improve congnition. Desensitization of nicotinic receptors is one of the novel approaches proposed by Buccafusco. Three of his compounds are currently in advanced preclinical evaluation.

D. Schoepp. - There is a medical need for novel antipsychotic drugs. Currently available drugs modulate dopamine receptors and do not affect cognitive domain of the disease. There also problems with compliance and tolerability of drugs. Schoepp advocates the use of glutamate receptor modulators in the therapy of schizophrenia.