A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

submitted by: enphpdom
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural...
Authors: P Dominguez-Salas, AM Prentice

Blurred Boundaries: The Therapeutics and Politics of Medical Marijuana.

submitted by: WentzMR

Dr. J. Michael Bostwick, Professor of psychiatry at Mayo Clinic in Rochester, MN, discusses his article appearing in the February 2012 issue of Mayo Clinic Proceedings on the potential benefits and current legal limitations for including marijuana in medical research. Available at: http://www.mayoclinicproceedings.org/article/S0025-6196(11)00021-8/fulltext

Correcting for Inflammation Changes Estimates of Iron Deficiency among Rural Kenyan Preschool Children

submitted by: ebogrant5
The assessment of iron status where infections are common is complicated by the effects of inflammation on iron indicators and in this study we compared approaches that adjust for this influence. Blood was collected in 680 children (aged 6–35 mo) and indicators of iron status [(hemoglobin (Hb), zinc protoporphyrin (ZP), ferritin, transferrin receptor (TfR), and TfR/ferritin index)] and subclinical inflammation [(the acute phase proteins (APP) C-reactive protein (CRP), and a-1-acid...
Authors: Frederick Grant, Parminder Suchdev, Rafael Flores-Ayala, Conrad Cole, Usha Ramakrishnan, Laird Ruth, Reynaldo Martorell

Decoding the Riddle of Mental Illness

submitted by: JohnLaMuth
Decoding the Riddle of Mental Illness through an overall communicational dynamic. The communicational factors underlying mental illness remain one of mankind's most enduring mysteries. Mental illness is primarily regarded as a physical disorder or a chemical imbalance, although clear-cut signs within the brain have eluded convincing documentation. Indeed, the most obvious outward signpost is a disturbance in the ability to communicate in an interpersonal sense, often in an exaggerated or...

Sexual Abuse and Lifetime Diagnosis of Psychiatric Disorders: Systematic Review and Meta-analysis

submitted by: mcgheekkm

Dr. Ali Zirakzadeh, Consultant in General Internal Medicine at Mayo Clinic in Rochester, MN, discusses his article on various disorders associated with sexual abuse and the most violent form of abuse, rape, in men and women.

Drug Discovery for Alzheimer's Disease

submitted by: alex01

Gregory Rose from PharmExperts.com interviews J. Buccafusco (Medical College of Georgia, Augusta, GA) about his development of new anti-Altzheimer drugs, designed to act by multiple mechanisms to improve congnition. Desensitization of nicotinic receptors is one of the novel approaches proposed by Buccafusco. Three of his compounds are currently in advanced preclinical evaluation.

Treatment of Psychosis

submitted by: alex01

D. Schoepp. - There is a medical need for novel antipsychotic drugs. Currently available drugs modulate dopamine receptors and do not affect cognitive domain of the disease. There also problems with compliance and tolerability of drugs. Schoepp advocates the use of glutamate receptor modulators in the therapy of schizophrenia.