Role of conserved non-linear structural motifs in the assembly of active protein kinases

submitted by: icamvid

Alexandr Kornev gives a talk at the RPP08 conference that includes:
1) Description of the LSP-alignment
2) Detection of a conserved nonlinear motif in protein kinases
3) Nonlinear motifs termed "spines" anchored to a single helix organize the kinase core.

Characterizing Protein Structures by Surface Mapping

submitted by: icamvid

Elaine Thompson gives a talk at the RPP08 conference about protein surface mapping:
1) Methods: Finding pockets on crystallographic structures with FADE and Crevasse Software
2) PKA Examples
3) Results on a Series of Kinases
4) Conclusions: Pocket

The folding and binding landscape of ankyrin repeat proteins

submitted by: icamvid

Elizabeth Komiups gives a talk at the RPP08 conference about the I?B? / NF-?B complex. She discusses the interface between the two proteins, the stabilization of the complex by "hotspots", and the folding of I?B? upon binding.

DFG motif: A Protonation Dependent Conformational Switch

submitted by: icamvid

Yibing Shan gives a talk at the RPP08 conference about the mechanism of DFG flip in Abl kinase:
1) Simulation of DFG flip
2) An energetic model: the role of protonation
3) Experimental test
4) What's the DFG flip for?

Free Energy Landscape, Conformational Changes and the Transduction of Biological Signals

submitted by: icamvid

Benoit Roux gives a talk at the RPP08 conference about free energy landscape, conformational changes and the transduction of biological signals. He also talks about the multiscale approaches to the activation, inactivation of Src kinases.

New Methods for Computer- Aided Drug Design and Atomically Detailed Models of Protein Regulation

submitted by: icamvid

Matt Jacobson discusses new methods for computer- aided drug design and atomically detailed models of protein regulation. He includes flexible binding sites, homology modeling, membrane permeability, physics- based scoring, phosphorylation, and pH defense.

Chemical Approaches to Investigating Protein Kinase Autophosphorylation

submitted by: icamvid

Phil Cole gives a talk at the RPP08 conference about:
1) Bisubstrate protein kinase inhibitors and expressed protein ligation
2) Investigation of protein kinase A intramolecular phosphorylation

Directional, Multi- Site Phosphorylations of an SR Protein Splicing Factor

submitted by: icamvid

Joe Adams talks about how splicing kinases phosphorylate multiple serine repeats. The important questions he adresses are whether they are processive or distributive, whether they are regio-specific or residue-specific, and whether they are directional.

Understanding Protein Kinase Structure

submitted by: icamvid

NataraJan Kannan discusses understanding protein kinase structure- function relationships using half a million genomic sequences.

Structural Insights into the KEOPS Complex: An Ancient Protein Kinase Containing Machine

submitted by: icamvid

Frank Sicheri talks about an ancient protein kinase containing machine that gives structural insights in the KEOPS complex. This includes the KEOPS structure, and its functions.