The Energy Landscape for Molecular Motors - the Kinesin Story

submitted by: icamvid

Jose Onuchic gives a talk at the RPP08 conference on the mechanics of molecular motors. The discussion includes:
1) The reflection of constraints of the molecular architecture the dynamical pathways during stepping
2) The role of rectified diffusional motion.

Structural insights into EGF Receptor activation

submitted by: icamvid

Diego Alvarado gives a talk at the RPP08 conference on:
1) the structure of the EGF Receptor
2) An insight into the role of the auto-inhibitory tether from invertibrate EGFR homologs

Modulation of the Kinase ensemble by Second Messengers

submitted by: icamvid

Michael Wall gives a talk at the RPP08 conference on:
1) Small-angle scattering studies of cGMP-dependent protein kinase
2) The challenge to understand how cellular signaling is controlled by modulation of protein conformational ensembles
3) Diffuse scattering

Electrostatics and long-range coupling in Src kinase activation

submitted by: icamvid

Carol Post gives a talk at the RPP08 conference on Src, a mechanism of conformational activation. She covers two topics regarding it Src:
1) Switched electrostatic network
2) long-range coupling of regulatory SH2/SH3 and catalytic domain

An Accelerated View of Functional Dynamics in Bio-Molecular Systems

submitted by: icamvid

Phineus Markwick gives a talk at the RPP08 conference long time-scale MD simulations of protein dynamics. He discusses experiments using dipolar coupling to probe the protein dynamics. From these he shows how to build a simulation.

Measure Molecular Interactions in Living Cells

submitted by: icamvid

Enrico Cratton gives a talk at the RPP08 conference about a "toolbox" to address questions regarding the formation of protein complex, their spatial distribution, and their stoichiometry.

Dynamics of Large-Scale Domain Motions in Protein Kinase A

submitted by: icamvid

Don Blumenth gives a talk at the RPP08 conference about the application of SAXS small-angle scattering to study the domain motions in Protein Kinase A and other protein kinases specifically in response to cAMP.