A new way forward for fibroblasts

submitted by: JCB
Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how cells move through three-dimensional environments is less well understood. Petrie et al. reveal that, depending on the strength of intracellular RhoA signaling and on the elastic properties of the extracellular matrix, fibroblasts can migrate through 3D environments using either lamellipodia or blunt, cylindrical protrusions called lobopodia. This biosights episode presents the...

T Cells Rho across the endothelium

submitted by: JCB
During an immune response, T cells move into tissues from the vasculature by crossing the endothelial cell layer lining blood vessel walls. Heasman et al. reveal that this transendothelial migration requires signaling at both the front and back of leukocytes by the small GTPase RhoA. This biosights episode presents the paper by Heasman et al. from the August 23, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Anne Ridley. Produced by Caitlin Sedwick...