The PDZ Domain as a Complex Adaptive System

submitted by: akourakine
Specific protein associations define the wiring of protein interaction networks and thus control the organization and functioning of the cell as a whole. Peptide recognition by PDZ and other protein interaction domains represents one of the best-studied classes of specific protein associations. However, a mechanistic understanding of the relationship between selectivity and promiscuity commonly observed in the interactions mediated by peptide recognition modules as well as its functional...
Authors: Alexei Kurakin, Andrzej Swistowski, Susan c. Wu, Dale e. Bredesen