Whole number and spacial distribution of the POU4f family of transcription factors in the adult rat retina

Quantification, distribution and coexpresion of the tree members of POU4F transcription factors in retinal ganglion cells in albino and pigmented rat retinas.

Cellular and Functional Optical Coherence Tomography of the Human Retina (The Cogan Lecture)

submitted by: arvojenny
An imaging modality that allows for fast, simultaneous, noninvasive probing of both three-dimensional (3D) cellular resolution retinal morphology and depth-resolved function could substantially improve the early diagnosis of various retinal diseases that are the leading causes of blindness worldwide and could contribute to a better understanding of retinal pathogenesis and enhanced therapy monitoring. In addition to user friendliness, reliability, and cost, the key technological parameters...
Authors: Wolfgang Drexler

Role of the Neural Crest in Vertebrate Development and Evolution - Part 2: The Role of the Neural Crest in Head Development and in Vertebrate Evolution (30:04)

submitted by: video_collector
Nicole Le Douarin shares her research on the role of the neural crest in skeletal development. The Q/C (quail/chick) marker system revealed that apart from the peripheral nervous system (PNS), the melanocytes and some endocrine tissues, the NC plays a major role in the construction of the vertebrate head. The entire facial skeleton and part of the skull (frontal, squamosal, parietal bones) are of NC origin together with the connective tissues of the face and ventral part of the neck. The...

The Vertebrate Retina: Structure, Function, and Evolution by Jeremy Nathans, Aug. 2008 - Part 1A: Photoreceptors and Image Processing (35:51)

submitted by: video_collector
In this set of lectures, Jeremy Nathans explores the molecular mechanisms within the retina that mediate the first steps in vision. The first lecture focuses on the structure of the light sensing receptors, the intracellular signals that are triggered by light absorption, and the ways in which the retina extracts information from a complex scene. For further information see: http://www.ascb.org/ibioseminars/Nathans/nathans1a.cfm

L-DOPA Is an Endogenous Ligand for OA1

submitted by: medtv
Albinism is a genetic defect characterized by a loss of pigmentation. The neurosensory retina, which is not pigmented, exhibits pathologic changes secondary to the loss of pigmentation in the retina pigment epithelium (RPE). How the loss of pigmentation in the RPE causes developmental defects in the adjacent neurosensory retina has not been determined, but offers a unique opportunity to investigate the interactions between these two important tissues. One of the genes that causes albinism...
Authors: Lopez Vm, Decatur Cl, Stamer Wd, Lynch Rm, Mckay Bs

I-DOPA is an Endogenous for OA1

submitted by: medtv

Brian S. McKay; Vanessa M. Lopez; Christina L. Decatur; W. Daniel Stamer; Ronald M. Lynch

Dendrites of rod bipolar cells sprout in normal aging retina

submitted by: Liets
The aging nervous system is known to manifest a variety of degenerative and regressive events. Here we report the unexpected growth of dendrites in the retinas of normal old mice. The dendrites of many rod bipolar cells in aging mice were observed to extend well beyond their normal strata within the outer plexiform layer to innervate the outer nuclear layer where they appeared to form contacts with the spherules of rod photoreceptors. Such dendritic sprouting increased with age and was...
Authors: Lauren c. Liets, Kasra Eliasieh, Deborah a. van der List, Leo m. Chalupa