Science Nation - Just by a Whisker

submitted by: nsf

From rats to robots: The story of the humble whisker. With funding from the National Science Foundation (NSF), Mitra Hartmann, associate professor at Northwestern's McCormick School of Engineering, and her students are beginning to get a feel for how animals perceive the world around them. The team starts by looking at one of the most powerful sensory systems in nature: the rat whisker system.

Introduction to the RGD Phenotypes and Models Portal

submitted by: jennifer.r.smith

Despite what our name might imply, the Rat Genome Database contains much more than just genomic and genetic data for the rat. This video will give you an overview of the RGD Phenotypes and Models portal—a rich resource of information on topics including animal husbandry, identifying what rat strains are good models for certain human diseases, and normal physiological measurements for a variety of rat strains.

A method for reduction of anesthetic waste gases produced by rodent induction chambers

submitted by: jhlvt

Reducing waste gas exposure produced by induction chambers

Rabbit Models for Alzheimer's Disease

submitted by: alex01

Diana Woodruff-Pak (Temple University, Philadelphia, PA) used cholesterol-fed rabbits as a model of AD for evaluation of currently available and potential anti-Alzheimer drugs. These animals developed typical Alzheimer pathology, including behavioral changes and deposition of ß-amyloid and even
tau. Galantamine and donepezil partially protected animals from Alzheimer symptomatology.

Treatment of Epilepsy

submitted by: alex01
Michael Rogawski (University of California, Davis) summarizes his research on the antiepileptic activity of neurosteroids (e.g. ganaxolone, allopregnanolone). They are allosteric modulators of GABAA receptors and are active in many models of epilepsy. They are expected, however, to be most effective in catamenial epilepsy, infantile spasms or adult partial seizures. National Institutes of Health (NIH) is currently sponsoring a clinical trial of progesterone (precursor of allopregnanolone)...

Therapies for Multiple Sclerosis

submitted by: alex01

J. Kocsis, PhD. - The current approaches to the therapy of multiple sclerosis are reviewed by J. Kocsis (Yale University). His research emphasizes remyelination as an approach to the therapy of multiple sclerosis and spinal cord injury.

Drug Discovery for Alzheimer's Disease

submitted by: alex01

Gregory Rose from PharmExperts.com interviews J. Buccafusco (Medical College of Georgia, Augusta, GA) about his development of new anti-Altzheimer drugs, designed to act by multiple mechanisms to improve congnition. Desensitization of nicotinic receptors is one of the novel approaches proposed by Buccafusco. Three of his compounds are currently in advanced preclinical evaluation.

Bacterial Inclusion Bodies Contain Amyloid-Like Structure

linked profile(s): Lei Wang
submitted by: apryl
Protein aggregation is a process in which identical proteins self-associate into imperfectly ordered macroscopic entities. Such aggregates are generally classified as amorphous, lacking any long-range order, or highly ordered fibrils. Protein fibrils can be composed of native globular molecules, such as the hemoglobin molecules in sickle-cell fibrils, or can be reorganized β-sheet–rich aggregates, termed amyloid-like fibrils. Amyloid fibrils are associated with several...
Authors: David Eisenberg, Samir K Maji, Roland Riek, Michael R Sawaya, Lei Wang

When it Comes to the Rat Genome, Bigger is Better

submitted by: dabraham
The rat genome comes to life through the use of the Gviewer tool. This video will show you how to use this helpful tool within the RGD website at http://rgd.mcw.edu/ . Genes, QTLs, and species syntenies of interest can all be visualized with ease as the Gviewer zooms in and navigates through the rat genome with a few clicks. See our website at http://rgd.mcw.edu/ for more tools for rat researchers.

Some prefer blue jeans...RGD prefers disease genes

submitted by: dabraham
Who knew you could find disease genes without even stepping into the laboratory? This video provides a tutorial on how to utilize the Disease Portals on the Rat Genome Database website at http://rgd.mcw.edu/wg/portals . These portals allow you to search for disease, phenotype, biological process, and pathway specific rat, mouse, and human genes and data. See our RGD website at http://rgd.mcw.edu for more information and tools for researchers...