Proteomics Platform for Biomarkers Discovery at Biogen Idec

submitted by: dougramsey

Talk by Jing Wei about "Proteomics Platform for Biomarkers Discovery at Biogen Idec"

Proteogenomics: Using Proteomic Data for Gene Annotation

submitted by: dougramsey

Talk by Vineet Bafna about "Proteogenomics: Using Proteomic Data for Gene Annotation"

Quantitative Global Proteome and Phosphoproteome Profiling of Human Embryonic Stem Cells Before and After Differentiation

submitted by: dougramsey

Talk by Zhouxin Shen about "Quantitative Global Proteome and Phosphoproteome Profiling of Human Embryonic Stem Cells Before and After Differentiation"

Hydrogen/Deuterium Exchange Mass Spectrometry for Structural Genomics

submitted by: dougramsey

Talk by Ansgar Brock about "Hydrogen/Deuterium Exchange Mass Spectrometry for Structural Genomics"

Driving Biological Discovery Using Quantitative Mass Spectrometry

submitted by: dougramsey

Talk by John Yates III about "Driving Biological Discovery Using Quantitative Mass Spectrometry"

Spectrometry and Calit2 Center for Algorithmic and Systems Biology

submitted by: dougramsey

Welcome talk by Nuno Bandeira about "Spectrometry and Calit2 Center for Algorithmic and Systems Biology"

Wiggle—Predicting Functionally Flexible Regions from Primary Sequence

submitted by: jgu
The Wiggle series are support vector machine–based predictors that identify regions of functional flexibility using only protein sequence information. Functionally flexible regions are defined as regions that can adopt different conformational states and are assumed to be necessary for bioactivity. Many advances have been made in understanding the relationship between protein sequence and structure. This work contributes to those efforts by making strides to understand the relationship...
Authors: Jenny Gu, Michael Gribskov, Philip E Bourne

Structural Evolution of the Protein Kinase–Like Superfamily

linked profile(s): Phil
submitted by: escheeff
The protein kinase family is large and important, but it is only one family in a larger superfamily of homologous kinases that phosphorylate a variety of substrates and play important roles in all three superkingdoms of life. We used a carefully constructed structural alignment of selected kinases as the basis for a study of the structural evolution of the protein kinase–like superfamily. The comparison of structures revealed a “universal core” domain consisting only of...
Authors: Eric d Scheeff, Philip e Bourne