Peptide ID and protein inference using PeptideProphet and ProteinProphet

submitted by: dachian

Advanced proteomics data analysis for identifying peptides and proteins with high sensitivity and specificity using proteomics mass-spectrometry.

The Evolution of Beta Amyloid Cleaving Enzyme (BACE1): an Alzheimer’s Disease Drug Target

submitted by: cdsouthan
Plaque formation in Alzheimer's Disease (AD) is seeded by excision products of Amyloid precursor protein (APP) generated by the combined activities of beta and gamma secretases. To reduce the production of these neurotoxic peptides the inhibition of beta-secretase (Beta-site APP Cleaving Enzyme, BACE1, Swiss-Prot P56817) is being intensively pursued as a possible therapy for AD and all drug candidates are screened for selectivity against the paralogue (BACE2, Swiss-Prot Q9Y5Z0) which...

Fast & reliable transition design using MRMaid: new analysis & results

submitted by: bixgurl

MRMaid [1] (pronounced ‘mermaid’) aims to answer the most challenging question faced by researchers attempting to perform MRM (multiple reaction monitoring).

Data Mining of Enzymes

submitted by: davidhorn

Protein functional prediction

Translational Proteomics 2.0 Meeting: SEQUEST and TPP Tips

submitted by: dachian

Advanced tips on using SEQUEST and TPP by Jimmy Eng of U. of Washington, the co-inventor of SEQUEST

The R403Q Myosin Mutation Implicated in Familial Hypertrophic Cardiomyopathy Causes Disorder at the Actomyosin Interface

submitted by: apryl
Background Mutations in virtually all of the proteins comprising the cardiac muscle sarcomere have been implicated in causing Familial Hypertrophic Cardiomyopathy (FHC). Mutations in the β-myosin heavy chain (MHC) remain among the most common causes of FHC, with the widely studied R403Q mutation resulting in an especially severe clinical prognosis. In vitro functional studies of cardiac myosin containing the R403Q mutation have revealed significant changes in enzymatic and...
Authors: Dorit Hanein, Larnele Hazelwood, Susan Lowey, HongJun Lui, Kathleen M. Trybus, Niels Volkmann

San Diego Science Festival -- Lunch with a Laureate -- Dr. Kurt Withrich

submitted by: sdscienccefestival

Nobel Laureate Kurt Wuthrich joins students of High Tech High - Chula Vista in an informal Q&A.

Metaproteomics as a key technology for characterizing the human microbiome Nathan C. VerBerkmoes, Oak Ridge National Labs

submitted by: dougramsey
The human microbiome is a complex system of many microbial communities inhabiting a diversity of environmental niches throughout the human body. With at least an order of magnitude more cells and even greater diversity of genetic potential these microbial communities continually interact with the human host cells in complex but controlled manner that lead to normal human health. Our knowledge of the structure and function of these communities and the interactions with the human host is...