Hyrdation Dynamics and Time Scales of Coupled Water-Protein Fluctuations

submitted by: icamvid

Dongping Zhong gives a talk at the ICAM 2007 conference about dynamical ordered water (conformational flexibility) and the dynamics of protein-water interactions.

Activation of Photoactive Yellow Protein

submitted by: icamvid

Gerrit Groenhof gives a talk at the ICAM 2007 conference about photon absorption, isomerization of the chromophore, structural changes, and signaling in photoactive yellow protein.

Cis-Trans Isomerism of Fluorescent Protein Chromosophores

submitted by: icamvid

Seth Olsen gives a talk at the ICAM 2007 conference about the properties of fluorescent protein chromophore isomers and how they connect with the protein's function.

Role of conserved non-linear structural motifs in the assembly of active protein kinases

submitted by: icamvid

Alexandr Kornev gives a talk at the RPP08 conference that includes:
1) Description of the LSP-alignment
2) Detection of a conserved nonlinear motif in protein kinases
3) Nonlinear motifs termed "spines" anchored to a single helix organize the kinase core.

Characterizing Protein Structures by Surface Mapping

submitted by: icamvid

Elaine Thompson gives a talk at the RPP08 conference about protein surface mapping:
1) Methods: Finding pockets on crystallographic structures with FADE and Crevasse Software
2) PKA Examples
3) Results on a Series of Kinases
4) Conclusions: Pocket

New Methods for Computer- Aided Drug Design and Atomically Detailed Models of Protein Regulation

submitted by: icamvid

Matt Jacobson discusses new methods for computer- aided drug design and atomically detailed models of protein regulation. He includes flexible binding sites, homology modeling, membrane permeability, physics- based scoring, phosphorylation, and pH defense.

Modulation of the Kinase ensemble by Second Messengers

submitted by: icamvid

Michael Wall gives a talk at the RPP08 conference on:
1) Small-angle scattering studies of cGMP-dependent protein kinase
2) The challenge to understand how cellular signaling is controlled by modulation of protein conformational ensembles
3) Diffuse scattering

An Accelerated View of Functional Dynamics in Bio-Molecular Systems

submitted by: icamvid

Phineus Markwick gives a talk at the RPP08 conference long time-scale MD simulations of protein dynamics. He discusses experiments using dipolar coupling to probe the protein dynamics. From these he shows how to build a simulation.

Measure Molecular Interactions in Living Cells

submitted by: icamvid

Enrico Cratton gives a talk at the RPP08 conference about a "toolbox" to address questions regarding the formation of protein complex, their spatial distribution, and their stoichiometry.

Dynamics of Large-Scale Domain Motions in Protein Kinase A

submitted by: icamvid

Don Blumenth gives a talk at the RPP08 conference about the application of SAXS small-angle scattering to study the domain motions in Protein Kinase A and other protein kinases specifically in response to cAMP.