Cell Organization & Cell Motility: Part 3: Principles of Cellular Organization: The Universal Cytoskeleton (29:17)

submitted by: scivee-team
In the third part, I discuss how the complex shapes of cells are created by the cytoskeleton, and I compare and contrast prokaryotes (which have actin-, tubulin-, and intermediate filament -like proteins) and eukaryotes in this regard. In particular, I speculate that cytoskeletal dynamics were necessary to evolve simple bacterial shapes and cell division, but that additional layers of complexity (namely regulated nucleation and molecular motors) allowed eukaryotes to evolve more complex...

Cell Organization & Cell Motility: Part 2: Force Generation by Actin Assembly: Theories and Experiments (46:16)

submitted by: scivee-team

The second part is devoted to understanding how the polymerization of actin can produce, which is a current area of research in our laboratory. Here, I cover theories for how polymerization might be used to produce forces, and our efforts to test these models using optical traps, atomic force microscopes, and nanofabricated devices.