Demo: Variation for the ZAP70 gene with Ensembl

submitted by: gspudich

We use the Ensembl genome browser at www.ensembl.org to view small scale sequence variants such as SNPs (single nucleotide polymorphims) along with larger structural variations like CNVs (copy number variation) for the human ZAP70 gene.

New Methods from the Berkeley Phylogenomics Group

submitted by: ruchira

Here we present two new algorithms hosted within the PhyloFacts phylogenomic encyclopedias.

Adaptation to Human Populations Is Revealed by Within-Host Polymorphisms in HIV-1 and Hepatitis C Virus

submitted by: art
CD8+ cytotoxic T-lymphocytes (CTLs) perform a critical role in the immune control of viral infections, including those caused by human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). As a result, genetic variation at CTL epitopes is strongly influenced by host-specific selection for either escape from the immune response, or reversion due to the replicative costs of escape mutations in the absence of CTL recognition. Under strong CTL-mediated selection, codon positions...
Authors: Art f. y Poon, Sergei l. kosakovsky Pond, Phil Bennett, Douglas d Richman, Andrew j. leigh Brown, Simon d. w Frost