Septins rein in the membrane

submitted by: JCB
T cells require the septin family of GTP-binding proteins to maintain the integrity of their plasma membranes as they invade through tissues. Gilden et al. reveal that septins function by assembling on membrane blebs to retract them back into shape. This biosights episode presents the paper by Gilden et al. from the January 9, 2012, issue of The Journal of Cell Biology and includes an interview with senior author Max Krummel (University of California, San Francisco). Produced by Caitlin...

Ouch! Single Cell Wound Repair in Drosophila Embryos

submitted by: JCB
Individual cells must quickly repair any disruptions to their plasma membrane. Abreu-Blanco et al. describe how early Drosophila embryos remodel their membranes and cytoskeleton to seal cell surface wounds. This biosights episode presents the paper by Abreu-Blanco et al. from the May 2, 2011 issue of The Journal of Cell Biology, and includes an interview with senior author Susan Parkhurst (Fred Hutchinson Cancer Research Center, Seattle, WA). Produced by Caitlin Sedwick and Ben Short....

Protein Secretion and Vesicle Traffic by Randy Schekman - Part 1: Genetic Dissection of the Secretory Pathway (36:35)

submitted by: video_collector
Protein secretion is executed by a cellular pathway involving the delivery of membrane and soluble secretory proteins in vesicles that capture newly-synthesized proteins assembled in the endoplasmic reticulum (ER) and sorted in the Golgi apparatus. Vesicles fuse with the plasma membrane resulting in the discharge of soluble molecules to the cell exterior and integration of vesicle membrane proteins and lipids in the cell surface. Baker's yeast cells grow by vesicle fusion and secretion at...

Membrane Rafts by Satyajit 'Jitu' Mayor, May 2007 - Part 1: Historical Perspective: What are Membrane Rafts? (38:19)

submitted by: video_collector
The plasma membrane demarcates the inside of the living cell from the outside, serving both as the ultimate physical barrier and location where the cell transacts its business with the outside world. The study of the structure of cell membranes continues to be fertile ground for research for many biologists today; the idea of "Membrane Rafts" has only heightened interest in this area. The main focus of this three part series is to explore the concept of "Membrane Rafts". In the first part,...