New Methods for Computer- Aided Drug Design and Atomically Detailed Models of Protein Regulation

submitted by: icamvid

Matt Jacobson discusses new methods for computer- aided drug design and atomically detailed models of protein regulation. He includes flexible binding sites, homology modeling, membrane permeability, physics- based scoring, phosphorylation, and pH defense.

Directional, Multi- Site Phosphorylations of an SR Protein Splicing Factor

submitted by: icamvid

Joe Adams talks about how splicing kinases phosphorylate multiple serine repeats. The important questions he adresses are whether they are processive or distributive, whether they are regio-specific or residue-specific, and whether they are directional.