Tuberculosis: A Persistent Threat to Global Health - Part 3: Phenotypic Heterogeneity and Antibiotic Tolerance (27:15)

submitted by: video_collector
The principal obstacle to successful treatment of tuberculosis is the lengthy duration of current regimens, which require administration of multiple drugs for 6-9 months. The requirement for prolonged therapy is attributed to sub-populations of bacillary "persisters" that are refractory to antimicrobials. The persisters are not drug-resistant in the conventional (heritable) sense and it is a mystery why they are spared whilst their genetically identical siblings are killed. The third part of...