Sodium Channels and Pain

submitted by: alex01

S. Waxman, MD, PhD. - Medical need for new analgesics is discussed by S. Waxman (Yale University) who evaluated the role of selective subtypes of sodium channels, particularly 1.7 and 1.8 subtypes, in the perception of pain. There is an unmet medical need for drugs to treat chronic pain and inhibitors of
selective sodium channels are in development as novel analgesics.

Cannabinoids

submitted by: alex01
Daniele Piomelli, PhD. - Another approach was discussed by D. Piomelli (University of California, Irvine). URB 597, an inhibitor of fatty acid amide hydrolase (FAAH), is expected to increase anandamide signaling and is being currently clinically tested in the therapy of pain. An increase in anandamide signaling may also be useful in the therapy of depression. This is a novel approach to the development of antidepressants. The signaling can be enhanced by blocking anadamide metabolism or by...

Drug Discovery for Alzheimer's Disease

submitted by: alex01

Gregory Rose from PharmExperts.com interviews J. Buccafusco (Medical College of Georgia, Augusta, GA) about his development of new anti-Altzheimer drugs, designed to act by multiple mechanisms to improve congnition. Desensitization of nicotinic receptors is one of the novel approaches proposed by Buccafusco. Three of his compounds are currently in advanced preclinical evaluation.

Translational Medicine

submitted by: alex01

J.E. Barrett, PhD. - Translational medicine attempts to translate basic research findings to medical need. There is a medical need for novel drugs for the therapy of diseases of the central nervous system. The major recent research achievements are greater insights into the disease processes, but innovation in pharmaceutical industry is declining. To stimulate innovation the industry should establish more partnerships with academic institutions.

An intrasubunit salt-bridge linking Loop A and Loop 2 is critical for GABAA receptor activation

submitted by: pv_srinivasan

Srinivasan Venkatachalan shares his poster presentation at the Experimental Biology 2008 conference.

Understanding receptor selectivity and ligand stereochemistry of insecticides and therapeutic agents for nicotinic acetylcholine receptor subtypes

submitted by: John.Yamauchi

John Yamauchi shares his poster presentation at the Experimental Biology 2008 conference.

Lacritin, a novel tear glycoprotein, stimulates tear production in rabbits without ocular toxicity

submitted by: scivee-team

Sandeep Samudre shares his poster presentation at the Experimental Biology 2008 conference.

The aquaporin 5 gene polymorphism AQP5-1364 A/C has no impact on loss of renal function in children following renal transplantation

submitted by: scivee-team

Rainer Buscher shares his poster presentation at the Experimental Biology 2008 conference.

Chronic exposure to beta-blockers attenuates inflammation and mucous metaplasia in a murine asthma model

submitted by: scivee-team

Long Nguyen shares his poster presentation at the Experimental Biology 2008 conference.

Epac is an integrator of pro- and anti-fibrotic signals in cardiac fibroblasts

submitted by: scivee-team

Nakon Aroonsakool shares his poster presentation at the Experimental Biology 2008 conference.