MyD88 knockout mice develop initial enlarged periapical

AIM: To characterize the formation and progression of experimentally induced periapical lesions in teeth of MyD88 knockout (MyD88 KO) mice compared with wild-type (WT) mice. METHODOLOGY: Periapical lesions were induced in the mandibular first molars of 30 WT and 30 MyD88 KO mice. After 7, 21 and 42 days, the animals were euthanized and the mandibles were subjected to histotechnical processing. Histological sections were stained with haematoxylin and eosin (HE), TRAP histoenzymology,...
Authors: Raquel Assed Bezerra da Silva, Paulo Nelson-Filho, Marília Pacífico Lucisano, Andiara De Rossi, Alexandra Mussolino de Queiroz, Lea Assed Bezerra da Silva

Surgical periodontal therapy with and without initial scaling and root planing in the management of chronic periodontitis: a randomized clinical trial

submitted by: drmanar
Aim: To compare the outcomes of surgical periodontal therapy with and without initial scaling and root planing. Methods: Twenty-four patients with severe chronic periodontitis were enrolled in this pilot, randomized controlled clinical trial. Patients were equally allocated into two treatment groups: Control group was treated with scaling and root planing, re-evaluation, followed by Modified Widman Flap surgery and test group received similar surgery without scaling and root planing....
Authors: Manar Aljateeli

Crevicular fluid biomarkers and periodontal disease progression

submitted by: Janet Kinney
AIM: Assess the ability of a panel of gingival crevicular fluid (GCF) biomarkers as predictors of periodontal disease progression (PDP). MATERIALS AND METHODS: 100 individuals participated in a 12-month longitudinal investigation and categorized into 4 groups according to their periodontal status. GCF, clinical parameters, and saliva were collected bi-monthly. Sub-gingival plaque and serum were collected bi-annually. For 6 months, no periodontal treatment was provided. At 6-months,...
Authors: Thomas Braun, William Giannobile, Janet Kinney, Thiago Morelli, Min Oh, Christoph Ramseier, James Sugai

Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study

Aim The aim of this randomized placebo-controlled clinical trial was to evaluate the effects of Lactobacillus reuteri-containing probiotic lozenges as an adjunct to scaling and root planing (SRP). Material and Methods Thirty chronic periodontitis patients were recruited and monitored clinically and microbiologically at baseline, 3, 6, 9 and 12 weeks after therapy. All patients received one-stage full-mouth disinfection and randomly assigned over a test (SRP + probiotic, n = 15) or...
Authors: Wim Teughels, Andac Durukan, Onur Ozcelik, Martine Pauwels, Marc Quirynen, Mehmet Cenk Haytac

Genome-wide association study of chronic periodontitis in a general German population

submitted by: ateumer
Aim: To identify loci associated with chronic periodontitis through a genome wide association study (GWAS). Materials and Methods: A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n=3365 and SHIP-TREND n=667) with the different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genomes based...
Authors: A Teumer, B Holtfreter, U Völker, A Petersmann, M Nauck, R Biffar, H Völzke, HK Kroemer, P Meisel, G Homuth, T Kocher

Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence

submitted by: WSB
Background: Periodontal disease and diabetes mellitus are common, chronic diseases worldwide. Epidemiologic and biologic evidence suggests periodontal disease may affect diabetes. Objective: To systematically review non-experimental, epidemiologic evidence for effects of periodontal disease on diabetes control, complications, and incidence. Data sources: Electronic bibliographic databases, supplemented by hand searches of recent and future issues of relevant journals. Study eligibility...
Authors: Wenche S. Borgnakke, Pekka V. Ylostalo, George W. Taylor, Robert R. Genco

Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.

submitted by: mferes
AIM: To evaluate the effects of the adjunctive use of metronidazole (MTZ) or MTZ + amoxicillin (AMX) in the treatment of generalized chronic periodontitis (ChP). A secondary aim was to examine a possible added effect of chlorhexidine to these therapies. METHODS: One hundred and eighteen subjects received scaling and root planing (SRP) only or with MTZ [400 mg/thrice a day (TID)] or MTZ+AMX (500 mg/TID) for 14 days. Half of the subjects in each group rinsed with 0.12% chlorhexidine twice a...
Authors: Magda Feres

All-cause mortality and periodontitis in 60–70-year-old men: a prospective cohort study

submitted by: Gerrylinden
Objective: To investigate the association between periodontitis and mortality from all causes in a prospective study in a homogenous group of 60-70 year-old Western European men. Methodology: A representative sample of 1400 dentate men, (mean age 63.8 SD 3.0 years), drawn from the population of Northern Ireland, had a comprehensive periodontal examination between 2001 and 2003. Men were divided into thirds on the basis of their mean periodontal attachment loss (PAL). The primary endpoint,...
Authors: Gerard Linden, Katie Linden, John Yarnell, Alun Evans, Frank Kee, Christopher Patterson

Cost-effectivness of an individually tailored oral health educational programme based on cognitive behavioural strategies in non-surgical periodontal treatment

submitted by: bjo
Aim: The aim of this cost-effectiveness analysis (CEA), performed from a societal perspective, was to compare costs and consequences of an individually-tailored oral health educational programme (ITOHEP) based on cognitive-behavioural strategies integrated in non-surgical periodontal treatment compared with a standard treatment programme (ST). Material and Methods: A randomised (n=113), evaluator-blinded, controlled trial, with two different active treatments, was analysed with respect to...
Authors: Birgitta Jönsson, Kerstin Öhrn, Per Lindberg, Nils Oscarson