Crevicular fluid biomarkers and periodontal disease progression

submitted by: Janet Kinney
AIM: Assess the ability of a panel of gingival crevicular fluid (GCF) biomarkers as predictors of periodontal disease progression (PDP). MATERIALS AND METHODS: 100 individuals participated in a 12-month longitudinal investigation and categorized into 4 groups according to their periodontal status. GCF, clinical parameters, and saliva were collected bi-monthly. Sub-gingival plaque and serum were collected bi-annually. For 6 months, no periodontal treatment was provided. At 6-months,...
Authors: Thomas Braun, William Giannobile, Janet Kinney, Thiago Morelli, Min Oh, Christoph Ramseier, James Sugai

Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study

Aim The aim of this randomized placebo-controlled clinical trial was to evaluate the effects of Lactobacillus reuteri-containing probiotic lozenges as an adjunct to scaling and root planing (SRP). Material and Methods Thirty chronic periodontitis patients were recruited and monitored clinically and microbiologically at baseline, 3, 6, 9 and 12 weeks after therapy. All patients received one-stage full-mouth disinfection and randomly assigned over a test (SRP + probiotic, n = 15) or...
Authors: Wim Teughels, Andac Durukan, Onur Ozcelik, Martine Pauwels, Marc Quirynen, Mehmet Cenk Haytac

Genome-wide association study of chronic periodontitis in a general German population

submitted by: ateumer
Aim: To identify loci associated with chronic periodontitis through a genome wide association study (GWAS). Materials and Methods: A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania (SHIP n=3365 and SHIP-TREND n=667) with the different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genomes based...
Authors: A Teumer, B Holtfreter, U Völker, A Petersmann, M Nauck, R Biffar, H Völzke, HK Kroemer, P Meisel, G Homuth, T Kocher

Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence

submitted by: WSB
Background: Periodontal disease and diabetes mellitus are common, chronic diseases worldwide. Epidemiologic and biologic evidence suggests periodontal disease may affect diabetes. Objective: To systematically review non-experimental, epidemiologic evidence for effects of periodontal disease on diabetes control, complications, and incidence. Data sources: Electronic bibliographic databases, supplemented by hand searches of recent and future issues of relevant journals. Study eligibility...
Authors: Wenche S. Borgnakke, Pekka V. Ylostalo, George W. Taylor, Robert R. Genco

Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.

submitted by: mferes
AIM: To evaluate the effects of the adjunctive use of metronidazole (MTZ) or MTZ + amoxicillin (AMX) in the treatment of generalized chronic periodontitis (ChP). A secondary aim was to examine a possible added effect of chlorhexidine to these therapies. METHODS: One hundred and eighteen subjects received scaling and root planing (SRP) only or with MTZ [400 mg/thrice a day (TID)] or MTZ+AMX (500 mg/TID) for 14 days. Half of the subjects in each group rinsed with 0.12% chlorhexidine twice a...
Authors: Magda Feres

All-cause mortality and periodontitis in 60–70-year-old men: a prospective cohort study

submitted by: Gerrylinden
Objective: To investigate the association between periodontitis and mortality from all causes in a prospective study in a homogenous group of 60-70 year-old Western European men. Methodology: A representative sample of 1400 dentate men, (mean age 63.8 SD 3.0 years), drawn from the population of Northern Ireland, had a comprehensive periodontal examination between 2001 and 2003. Men were divided into thirds on the basis of their mean periodontal attachment loss (PAL). The primary endpoint,...
Authors: Gerard Linden, Katie Linden, John Yarnell, Alun Evans, Frank Kee, Christopher Patterson

Cost-effectivness of an individually tailored oral health educational programme based on cognitive behavioural strategies in non-surgical periodontal treatment

submitted by: bjo
Aim: The aim of this cost-effectiveness analysis (CEA), performed from a societal perspective, was to compare costs and consequences of an individually-tailored oral health educational programme (ITOHEP) based on cognitive-behavioural strategies integrated in non-surgical periodontal treatment compared with a standard treatment programme (ST). Material and Methods: A randomised (n=113), evaluator-blinded, controlled trial, with two different active treatments, was analysed with respect to...
Authors: Birgitta Jönsson, Kerstin Öhrn, Per Lindberg, Nils Oscarson