Validation of an In Vitro Digestive System

submitted by: KopfBolanz
The digestive process transforms nutrients and bioactive compounds contained in food to physiologically active compounds. In vitro digestion systems have proven to be powerful tools for understanding and monitoring the complex transformation processes that take place during digestion. Moreover, the investigation of the physiological effects of certain nutrients demands an in vitro digestive process that is close to human physiology. In this study, human digestion was simulated with a 3-step...
Authors: KA Kopf-Bolanz, F Schwander, M Gijs, G Vergères, R Portmann, L Egger

Sodium Channels and Pain

submitted by: alex01

S. Waxman, MD, PhD. - Medical need for new analgesics is discussed by S. Waxman (Yale University) who evaluated the role of selective subtypes of sodium channels, particularly 1.7 and 1.8 subtypes, in the perception of pain. There is an unmet medical need for drugs to treat chronic pain and inhibitors of
selective sodium channels are in development as novel analgesics.

Conus Peptides by Baldomero "Toto" Olivera, May 2006 - Part 1: Historical Background: Discovery of a Drug (23:40)

submitted by: video_collector
Although snails are not the first animals that come to mind when venoms are mentioned, there are in fact a large number (~10,000 species) of different venomous predatory snails. The most intensively studied of these are the cone snails (Conus), which have a large number of peptide neurotoxins present in their venoms. Some cone snail venoms are lethal to man; one species causes a 70% fatality rate. How these venoms have been used to understand the nervous system, and how the characterization...

Magnetic Separation

submitted by: andrewinoslo

Magnetic separation technology was pioneered by Dynal for the separation of biomagnetic material. Dynabeads technology supports genomics, transcriptomics, proteomics, diagnostics, basic research, clinical cell