Grape Powder Supplementation Prevents Oxidative Stress–Induced Anxiety-Like Behavior, Memory Impairment, and High Blood Pressure in Rats

submitted by: ssalim
We examined whether or not grape powder treatment ameliorates oxidative stress–induced anxiety-like behavior, memory impairment, and hypertension in rats. Oxidative stress in Sprague-Dawley rats was produced by using L-buthionine- (S,R)-sulfoximine (BSO). Four groups of rats were used: 1) control (C; injected with vehicle and provided with tap water), 2) grape powder–treated (GP; injected with vehicle and provided for 3 wk with 15 g/L grape powder dissolved in tap water), 3)...
Authors: Farida Allam, An Dao, Gaurav Chugh, Ritu Bohat, Faizan Jafri, Gaurav Patki, Christopher Mowrey, Mohammad Asghar, Karim Alkadhi, Samina Salim

Stroke gene discovered

submitted by: CRoulaux
A Dutch-German medical research team led by Harald Schmidt from Maastricht University, Netherlands, and Christoph Kleinschnitz, University of Würzburg, Germany, in cooperation with Helmholz Zentrum München, has discovered that an enzyme is responsible for the death of nerve cells after a stroke. The enzyme NOX4 produces hydrogen peroxide, a caustic molecule also used in bleaching agents. Inhibition of NOX4 in mice by an experimental new drug dramatically reduces brain damage and preserves...