Neuronal autophagosomes mature on the move

submitted by: JCB
Autophagy is a cellular degradation pathway essential for neuronal survival, but little is known about the dynamics of autophagic organelles in neurons. Maday et al. reveal that autophagosomes form and engulf cargo at the distal tips of neurites and then mature into degradative autolysosomes as they move toward the cell body. This biosights episode presents the paper by Maday et al. from the February 20, 2012, issue of The Journal of Cell Biology and includes an interview with authors Sandra...

Acetylated microtubules let the ER slide

submitted by: JCB
The endoplasmic reticulum is highly dynamic, although little is known about why and how its membrane tubules move. Friedman et al. reveal that ER membranes slide along stable, acetylated microtubules, which might help them contact other organelles such as mitochondria. This biosights episode presents the paper by Friedman et al. from the August 9, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Gia Voeltz. Produced by Caitlin Sedwick and Ben Short....