biosights: August 6, 2012 - Redistribution aids the pore

submitted by: JCB
In animal cells, the nuclear lamina keeps nuclear pore complexes evenly distributed throughout the nuclear envelope. Steinberg et al. reveal that fungi, which lack nuclear laminae, prevent their nuclear pores from clustering by moving them around on cytoskeletal tracks, a process that also helps to organize fungal chromosomes and optimize nucleocytoplasmic transport. This biosights episode presents the paper by Steinberg et al. from the August 6, 2012, issue of The Journal of Cell Biology...

Nuclear envelope starts with a clean sheet

submitted by: JCB
At the start of mitosis, the nuclear envelope and nuclear pore complexes break down and disperse into the endoplasmic reticulum and cytoplasm. Lu et al. use rapid, 3D live cell imaging to reveal that, in contrast to previous models, the nuclear envelope reforms directly from ER cisternae after mitosis and that this happens before nuclear pore complexes start to reassemble. This biosights episode presents the paper by Lu et al. from the August 8, 2011, issue of The Journal of Cell Biology,...

Nup133 is a Pore Relation to the Centrosome

submitted by: JCB
The centrosome remains closely associated with the nucleus throughout the cell cycle. Bolhy et al. reveal that the nucleoporin Nup133 anchors a network of proteins, including the motor protein dynein, that tethers centrosomes to nuclear pores in early prophase to assist the early stages of mitotic spindle assembly. This biosights episode presents the paper by Bolhy et al. from the March 7, 2011, issue of The Journal of Cell Biology, and includes an interview with senior author Valérie Doye...