Nicotine Adiction

submitted by: alex01
Linda Dwoskin (Univerisity of Kentucky, Lexington, KY) discussed drugs currently used for nicotine addiction, including various formulations of nicotine, bupropion (Zyban@) and varenicline (Chantix@) as well as her research on novel antagonists of nicotinic receptors. According to Dwoskin a6ß2 subtype of nicotinic receptors may represent a better target for novel antagonists for smoking cessation. This is, however, not the only receptor subtype involved in nicotine addiction. Other...

Drug Discovery for Alzheimer's Disease

submitted by: alex01

Gregory Rose from PharmExperts.com interviews J. Buccafusco (Medical College of Georgia, Augusta, GA) about his development of new anti-Altzheimer drugs, designed to act by multiple mechanisms to improve congnition. Desensitization of nicotinic receptors is one of the novel approaches proposed by Buccafusco. Three of his compounds are currently in advanced preclinical evaluation.