We report on a systematic analysis of genotype-specific melanocyte (MC) UVR responses in transgenic mouse
melanoma models along with tumour penetrance and comparative histopathology. pRb or p53 pathway
mutations cooperated with NrasQ61K to transform MCs. We previously reported that MCs migrate from the
follicular outer root sheath into the epidermis after neonatal UVR. Here, we found that Arf or p53 loss markedly
diminished this response. Despite this, mice carrying these mutations...
Authors: Graeme Walker, Blake Ferguson