Sodium Channels and Pain

submitted by: alex01

S. Waxman, MD, PhD. - Medical need for new analgesics is discussed by S. Waxman (Yale University) who evaluated the role of selective subtypes of sodium channels, particularly 1.7 and 1.8 subtypes, in the perception of pain. There is an unmet medical need for drugs to treat chronic pain and inhibitors of
selective sodium channels are in development as novel analgesics.

Neuropathic Pain Neurodegenerative Disease

submitted by: alex01

Dr. Remi Quirion (McGill University, Montreal, Quebec, Canada) described enhancement of the effects of pain-related peptides by PGE2 . This finding suggests a new, possible complimentary approach to the therapy of pain. Qurion also discussed anti-Alzheimer effect of polyphenols. This effect appears to be due not due to their antioxidant activity only. Quirion suggested the existence of membrane protein than binds polyphenols.

Cannabinoids

submitted by: alex01
Daniele Piomelli, PhD. - Another approach was discussed by D. Piomelli (University of California, Irvine). URB 597, an inhibitor of fatty acid amide hydrolase (FAAH), is expected to increase anandamide signaling and is being currently clinically tested in the therapy of pain. An increase in anandamide signaling may also be useful in the therapy of depression. This is a novel approach to the development of antidepressants. The signaling can be enhanced by blocking anadamide metabolism or by...