Bacillus thuringiensis Cry5B Protein Is Highly Efficacious as a Single-Dose Therapy against an Intestinal Roundworm Infection in

submitted by: raroian
Latest research from UCSD on new, powerful cure against intestinal parasitic roundworms (soil transmitted helminths) like hookworms, whipworms, and Ascaris. These parasites infect 2 billion of the poorest peoples and are a leading source of disease burden in school-aged children. The world has virtually ignored the issues of less than adequate drugs and emerging parasite resistance. Here we turn to an organic solution, natural soil bacterium Bacillus thuringiensis crystal protein (Cry5B)....

The New Anthelmintic Tribendimidine is an L-type (Levamisole and Pyrantel) Nicotinic Acetylcholine Receptor Agonist

submitted by: raroian
Background Intestinal parasitic nematodes such as hookworms, Ascaris lumbricoides, and Trichuris trichiura are amongst most prevalent tropical parasites in the world today. Although these parasites cause a tremendous disease burden, we have very few anthelmintic drugs with which to treat them. In the past three decades only one new anthelmintic, tribendimidine, has been developed and taken into human clinical trials. Studies show that tribendimidine is safe and has good clinical...
Authors: Yan Hu, Shu-Hua Xiao, Raffi V. Aroian

Neglected disease research and development: how much are we really spending

submitted by: mparkinson
The need for new pharmaceutical tools to prevent and treat neglected diseases is widely accepted. The creation of a vaccine for HIV/AIDS, more effective diagnostics for tuberculosis (TB), and better treatments for leishmaniasis and sleeping sickness would greatly improve health in the developing world in line with the United Nations Millennium Development Goals. However, funders wishing to invest in this vitally important area currently face an information gap. There is little consensus on...
Authors: Mary Moran, Javier Guzman, Anne-laure Ropars, Alina Mcdonald, Nicole Jameson, Brenda Omune, Sam Ryan, Lindsey Wu