A Mathmatical Model of Force Transmission by Desmin in Skeletal Muscle

submitted by: gmeyer
The desmin intermediate filament network in skeletal muscle fibers has been proposed to play a pivotal role in force transmission and maintenance of structural alignment among myofibrils. Fibers from desmin knockout muscles have demonstrated lower isometric stress production and increased sarcomere misalignment in both active and passive deformations. Though it is apparent that desmin filaments affect the mechanical properties of skeletal muscle, the mechanism for such an effect is unclear.