Oocyte microtubules show their bias

submitted by: JCB
Several mRNAs are specifically transported to the anterior and posterior regions of Drosophila oocytes by microtubule-based motor proteins, but the organization of microtubules in these cells is unclear. Parton et al. reveal that oocyte microtubules are highly dynamic and display a PAR-1-dependent bias in polarity that facilitates transport of oskar mRNA to the oocyte posterior. This biosights episode presents the paper by Parton et al. from the July 11, 2011, issue of The Journal of Cell...

Microtubules Keep Tumor Cells Breathing Easy

submitted by: JCB
The transcription factor HIF-1α is essential for a cell's response to low oxygen conditions. Carbonaro et al. demonstrate that production of HIF-1α protein is regulated by dynamic microtubules and that microtubule-targeting drugs shift HIF-1α mRNA into cytoplasmic P-bodies, where its translation is repressed by miRNAs. This biosights episode presents the paper by Carbonaro et al. from the January 10, 2011, issue of The Journal of Cell Biology, and includes an interview with authors Marisa...

The Biology of Genomes (2008) with David Bentley Interviewed by Chris Gunter

Dr. David Bentley is Vice President and Chief Scientist at Illumina Inc, developing new DNA sequencing technology for fast, accurate sequencing of complex genomes. His major research interest is the study of human sequence variation. He was previously Head of Human Genetics and founding Member of the Board of Management at the Wellcome Trust Sanger Institute, where he played leading roles in the Institute's contribution the human genome reference sequence, The SNP Consortium and the...

Accessing the Metatranscriptome for Complex Marine Microbial Communities

submitted by: dougramsey
Sequencing the expressed genetic information of an ecosystem (metatranscriptome) can provide information about the response of organisms to varying environ mental conditions. Until recently, metatranscriptomics has been limited to microarray technology and random cloning methodologies. The application of high-throughput sequencing technology is now enabling access to both known and previously unknown transcripts in natural com munities. We present a study of a complex marine meta...

Array CGH Computational Lab - Chris Miller

submitted by: ralanharris

An introduction to computational methods for analyzing Array Comparative Genomic Hybridization data by Chris Miller. This was presented as a lab within the Computer Aided Discovery Methods course offered within the Graduate Program at Baylor College of Medicine.

Protein Synthesis

submitted by: jmath

A demosntration of Protein synthesis expressed through dance. The film was directed in 1971 by Robert Alan Weiss for the Department of Chemistry of Stanford University and narrated by Paul Berg, a 1980 Nobel Prize winner for Chemistry. It is imprinted with the "free love" aura of the period, and continues to be shown in biology classes today. It has inspired a series of similar funny attempts at vulgarizing protein synthesis.