Pulling centrosomes to the forward position

submitted by: JCB
Most migrating cells place their centrosome in front of the nucleus, facing the direction in which the cell is moving. Manneville et al. identify a signaling pathway that moves the centrosome into position by recruiting the motor protein dynein to leading edge microtubules. This biosights episode presents the paper by Manneville et al. from the November 1, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Sandrine Etienne-Manneville (Institut Pasteur,...