Role of conserved non-linear structural motifs in the assembly of active protein kinases

submitted by: icamvid

Alexandr Kornev gives a talk at the RPP08 conference that includes:
1) Description of the LSP-alignment
2) Detection of a conserved nonlinear motif in protein kinases
3) Nonlinear motifs termed "spines" anchored to a single helix organize the kinase core.

Epigenomics of Cancer - Prof. Wei Li (Part 1, 2009)

submitted by: ralanharris

Prof. Wei Li lectures on studies of transcription factor binding sites and histone modifications using ChIP-chip and Chip-seq assays. Part of the Computer Aided Discovery Methods 2009 course offered at Baylor College of Medicine.

Sodium Channels and Pain

submitted by: alex01

S. Waxman, MD, PhD. - Medical need for new analgesics is discussed by S. Waxman (Yale University) who evaluated the role of selective subtypes of sodium channels, particularly 1.7 and 1.8 subtypes, in the perception of pain. There is an unmet medical need for drugs to treat chronic pain and inhibitors of
selective sodium channels are in development as novel analgesics.