De geschiedenis van de Pathologie, een reis door de archieven

submitted by: LUMC_PA_MD
Technologische vooruitgang in de pathologie. Een reis door de archieven. Van anatomisch theater naar “gepersonaliseerde geneeskunde”. Deze video presentatie is gemaakt ten behoeve van de promotie van Ronald van Eijk d.d. 8 mei 2013 op het proefschrift: Technological Advances in Molecular Pathology. A journey into the Archives De presentatie geeft een populair wetenschappelijk beeld van de ontwikkelingen in de Pathologie. In de loop der eeuwen zijn er vele revolutionaire, breed...

Strong Electron Correlation Effects in Transition Metal Complexes: from Molecular Transitions to Absorption Spectra of Metalloproteins

submitted by: icamvid

Daniel Cox gives a talk at the ICAM 2007 conference about electron correlation on the molecular level and it's connection to the Anderson model, X-ray absorption, and molecular ransistors.

Molecular Dynamics Simulations of Biomolecules in Water

submitted by: icamvid

Alan Mark gives a talk at the ICAM 2007 conference about the challenge of molecular dynamics simulations of biomolecules in water in terms of accuracy, uncertainty, and scale.

The Energy Landscape for Molecular Motors - the Kinesin Story

submitted by: icamvid

Jose Onuchic gives a talk at the RPP08 conference on the mechanics of molecular motors. The discussion includes:
1) The reflection of constraints of the molecular architecture the dynamical pathways during stepping
2) The role of rectified diffusional motion.

An Accelerated View of Functional Dynamics in Bio-Molecular Systems

submitted by: icamvid

Phineus Markwick gives a talk at the RPP08 conference long time-scale MD simulations of protein dynamics. He discusses experiments using dipolar coupling to probe the protein dynamics. From these he shows how to build a simulation.

Scott S. Terhune, Ph.D.

submitted by: MCW_BBC

Scott S. Terhune, Ph.D., an assistant professor in Microbiology and Molecular Genetics and the Biotechnology and Bioengineering Center at the Medical College of Wisconsin, describes his research in proteomics, mass spectrometry and Human Cytomeglavirus (HCMV).

Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection

submitted by: Ben_Norman
Staphylococcus aureus is a frequent cause for serious, chronic and therapy-refractive infections in spite of susceptibility to antibiotics in vitro. In chronic infections, altered bacterial phenotypes, such as small colony variants (SCVs), have been found. Yet, it is largely unclear whether the ability to interconvert from the wild-type to the SCV phenotype is only a rare clinical and/or just laboratory phenomenon or is essential to sustain an infection. Here, we performed different...
Authors: L Tuchscherr, E Medina, M Hussain, W Volker, V Heitmann, S Niemann, D Holzinger, J Roth, R Proctor, K Becker, G Peters, B Loffler

Magic of Life

submitted by: AlarEnsis

A quick (possible too much so) introduction to the Central Dogma of Molecular Biology (DNA to RNA to Protein) with fast audio and intuitive images.

Rabbit Models for Alzheimer's Disease

submitted by: alex01

Diana Woodruff-Pak (Temple University, Philadelphia, PA) used cholesterol-fed rabbits as a model of AD for evaluation of currently available and potential anti-Alzheimer drugs. These animals developed typical Alzheimer pathology, including behavioral changes and deposition of ß-amyloid and even
tau. Galantamine and donepezil partially protected animals from Alzheimer symptomatology.

TGFß & Alzheimer's Disease

submitted by: alex01

R.A. Flavell (Yale University, New Haven, CT) discusses the role of Transforming Growth Factor ß (TGFß) in disease. In the central nervous system of a murine model of AD this cytokine appears to prevent macrophages from attacking ß-amyloid. Flavell visualizes that selective blockade of this TGFß
activity could lead to the destruction of plaques in patients with AD.