Long Asters Rock The Spindle

submitted by: JCB
Astral microtubules help position the cytokinetic furrow by confining actomyosin contractility to the cell equator. Rankin and Wordeman reveal that if astral microtubules grow too long, they expand membrane blebs at the mitotic cell poles that squeeze the mitotic spindle back and forth between the two daughter cells. This biosights episode presents the paper by Rankin and Wordeman from the July 12, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Linda...

Systems biology of the mitotic spindle

submitted by: JCB
A novel high-throughput screening approach that combines yeast mutant arrays with high-content imaging provides fresh insights into mitotic spindle disassembly. This biosights episode presents the paper by Vizeacoumar et al. from the January 11, 2010 issue of The Journal of Cell Biology, and includes interviews with authors Brenda Andrews and Charles Boone, and JCB editorial board member John Aitchison. Produced by Eun Choi. Read the complete paper at:...