Mitochondria

Dr. Michael Spedding published recently a review on the role of cytokines and neurotrophins in disease. Neurotrophins (e.g. BDNF) have beneficial effects on neuronal plasticity and brain metabolism. Inflammatory cytokines (e.g. IL1beta)oppose the effects of neurotrophins. Both, neurotrophins and cytokines are targets for the development of new drugs affecting central nervous system. Brain-derived neurotrophic factor (BDNF) is the main activity-dependent neurotrophic factor. Interleukin 1beta...

Even though Brodie is said to have first described diffuse symmetrical lipomatosis with predilection for the neck already in the 1846 (Clinical Lectures on Surgery, Delivered at St. George's Hospital Philadelphia: Lea and Blanchard pub. Pp 201-201. Brodie, B.C.) still unknown is today the pathogenesis of Launois Bensaude' Lipomatosis. Klopstock et Al. are found in muscle biopsy specimens ragged and red fibers, pathologic subsarcolemmal accumulations of mitochondria, suggesting a...