CKIδ Decentralizes the Centrosome

submitted by: JCB
When a T cell encounters a target antigen-presenting cell, the lymphocyte's centrosome relocalizes to a specialized contact between the two cells called the immunological synapse. Zyss et al. reveal that casein kinase Iδ helps to reposition the centrosome in activated T cells, perhaps by working with the microtubule plus-end binding protein EB1 to regulate microtubule growth. This biosights episode presents the paper by Zyss et al. from the November 28, 2011, issue of The Journal of Cell...

Oocyte microtubules show their bias

submitted by: JCB
Several mRNAs are specifically transported to the anterior and posterior regions of Drosophila oocytes by microtubule-based motor proteins, but the organization of microtubules in these cells is unclear. Parton et al. reveal that oocyte microtubules are highly dynamic and display a PAR-1-dependent bias in polarity that facilitates transport of oskar mRNA to the oocyte posterior. This biosights episode presents the paper by Parton et al. from the July 11, 2011, issue of The Journal of Cell...

Tying the Golgi Ribbon to the Centrosome

submitted by: JCB
The mammalian Golgi apparatus exists as a continuous ribbon that clusters around the centrosome, but the significance of this organization is unclear. Hurtado et al. identify truncation mutants of the protein AKAP450 that differentially affect Golgi integrity and positioning, and use these mutants to investigate how the Golgi's organization contributes to its function in cell polarization, migration, and ciliogenesis. This biosights episode presents the paper by Hurtado et al. from the May...

Laminin Adhesions Help Microtubules Reach Base

submitted by: JCB
Microtubules align along the apical-basal axis of epithelial cells with their plus ends pointing to the basal side. Hotta et al. reveal how signals from the extracellular matrix establish this arrangement by recruiting the microtubule-anchoring factors LL5s to the basal cell cortex. This biosights episode presents the paper by Hotta et al. from the May 31, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Yuko Mimori-Kiyosue. Produced by Caitlin...