Nikos Krypides on "Analysis of metagenomic sequences: from megabases to terabases"

submitted by: JGI

Nikos Krypides of the DOE Joint Genome Institute discusses metagenomics and the challenge of dealing with terabases of data on June 4, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM.

International Soil Metagenome - Sequencing Project

submitted by: dougramsey
Soil is often considered to be one of the main reservoirs of microbial diversity on the planet. This diversity could provide a range of information about the origins of microbial functional diversity as well as novel genetic resources. However, our historical inability to cultivate the majority of soil bacteria has hampered our understanding and exploitation of this large diverse community (more than 95% are often considered inaccessible through traditional culture techniques). Over the last...

Genomic and Genetic Insight into Gut Microbiota Function and Manipulation

submitted by: dougramsey
Trillions of microbes live in our digestive tract and influence our biology in profound and diverse ways. Several diseases, including obesity and inflammatory bowel diseases, have been associated with large-scale shifts in microbiota composition. The ability to address basic questions concerning community function and plasticity are fundamental to understanding the extent of causal relationships between host biology and microbiota perturbations, and whether the microbiota is a viable...

New Insights Into Lignocellulose Conversion by Termite Gut Microbes

submitted by: dougramsey

Termites and their complex hindgut microbiota are able to convert wood lignocellulose into hydrogen and other products used to fuel their metabolisms. Recent gene and genome and metagenome based analyses on the gut community have revealed novel insights into many bacteria-mediated, important symbiotic functions. The system-wide gene analysis of a microbial community specialized towards plant lignocellulose degradation has both basic and applied implications.

Comparative Metagenomics

submitted by: dougramsey
Each metagenome study of a complex habitat is accompanied by lots of unknowns as so far the depth of sequencing is usually insufficient to reveal the entire microbial community of an ecosystem. The probably easiest way of extracting meaningful information is the comparison with existing data, analogous to that of genome comparisons. However, the complexity within the analysis chain of a single metagenome annotation is topped by the difficulties that the integration of heterogeneously...