TB Programming in BC

submitted by: bccdc

Describes how the TB program for British Columbia is implemented including screening, treatment, testing and locations around the province.

Tip of the Week: Comparing Microbial Databases

submitted by: OpenHelix

In this tip of the week by OpenHelix, I will briefly compare two great microbial databases - the UCSC Microbial Genome Browser & the Integrated Microbial Genomes or IMG resource. More details and microbial resources are included in the full post, which can be accessed at http://blog.openhelix.eu/?p=5651

Genetically Programmable Pathogen Sense and Destroy

submitted by: saurabh gupta

The video describes my invention of Engineered cells which can act as a live vaccine. These cells are programmed to intelligently detect a particular gut pathogen and then specifically and completely kill it without affecting the normal gut microbial flora. This automated approach thus prevents from horrible side effects of current antibiotics and growing resistance against them.

Jay Keasling's keynote address at 2010 DOE JGI User Meeting

submitted by: JGI

Jay Keasling, CEO of the Joint BioEnergy Institute, delivers the opening keynote on March 24, 2010 at the 5th Annual DOE JGI User Meeting.

David Mead on "Next Generation DNA Polymerases & Reverse Transcriptases"

submitted by: JGI

David Mead of Lucigen Corporation discusses polymerase development, Yellowstone and sequencing at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM on May 28, 2009.

Tim Harkins on "The 8 day challenge for 8 genomes"

submitted by: JGI

Tim Harkins of Roche Diagnostics talks about what he calls "The Edwards & Eisen Challenge" at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM on May 27, 2009.

Jessica Hostetler on "Human Microbiome Finishing"

submitted by: JGI

Jessica Hostetler from The J. Craig Venter Institute speaks at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM on May 27, 2009.

Tuberculosis: A Persistent Threat to Global Health - Part 4: Targeting M. tuberculosis Carbon Metabolism In Vivo (26:12)

submitted by: video_collector
All pathogens must acquire and assimilate nutrients from their hosts in order to grow and multiply -- our tissues are literally their food -- yet surprisingly little is known about this fundamental aspect of the pathogenic lifestyle. Accumulating evidence suggests that M. tuberculosis might utilize fatty acids as its principal carbon and energy source during infection. The fourth part of this lecture describes work in our laboratory that is focused on identifying the metabolic pathways that...

Tuberculosis: A Persistent Threat to Global Health - Part 3: Phenotypic Heterogeneity and Antibiotic Tolerance (27:15)

submitted by: video_collector
The principal obstacle to successful treatment of tuberculosis is the lengthy duration of current regimens, which require administration of multiple drugs for 6-9 months. The requirement for prolonged therapy is attributed to sub-populations of bacillary "persisters" that are refractory to antimicrobials. The persisters are not drug-resistant in the conventional (heritable) sense and it is a mystery why they are spared whilst their genetically identical siblings are killed. The third part of...

Tuberculosis: A Persistent Threat to Global Health - Part 2: Tools for Tuberculosis Control: Not Just a Problem of Implementation (28:18)

submitted by: video_collector
Tuberculosis remains one of the most important causes of human disease and death despite the introduction of vaccination in 1921 and chemotherapy in 1952. Although these interventions are inexpensive and widely available their impact is limited. The effectiveness of vaccination is unclear; in clinical trials, the protection conferred by vaccination has been variable and generally poor. Although chemotherapy can be highly effective, multiple drugs must be administered for 6-9 months to...