Protathlites part 1

submitted by: fleming

BSRC Alexander Fleming Protathlites part 1

Protathlites part 2

submitted by: fleming

BSRC Alexander Fleming Protathlites part 2

Partha Mitra explains his mouse brain research

submitted by: nsf

Partha Mitra of Cold Spring Harbor Laboratory is currently focused on the Mouse Brain Architecture Project (MAP), which is aimed at creating 3-D maps of the mouse brain at various scales.

New solution for therapeutic cancer vaccine failure

submitted by: mdanderson
http://www.mdanderson.org/newsroom/news-releases/2013/cancer-vaccines-ch... Vaccines designed to turn the immune system against cancer have been logically constructed and tested against many cancers. Almost all have failed or shown minimal effect. They spark creation of killer T cells against the cancer, but generally have little effect on tumors, both in patients and mouse models. Willem Overwijk, Ph.D., and colleagues at MD Anderson discovered that a common vaccine component is...

Dietary Selenium Deficiency Partially Rescues Type 2 Diabetes–Like Phenotypes of Glutathione Peroxidase-1–Overexpressing Male Mice

submitted by: xlei
This study was conducted to determine whether dietary Se deficiency precluded overproduction of glutathione peroxidase-1 (GPX1) activity in mice overexpressing (OE) this gene and thus rescued their type 2 diabetes–like phenotypes. A total of 20 male OE and wild-type (WT) mice were fed an Se-deficient (<0.02 mg/kg) diet or an Se-supplemented (0.3 mg/kg as sodium selenite) diet from 1 to 5 mo of age. Dietary Se deficiency eliminated or attenuated (P < 0.05) genotype differences in...
Authors: Xin Gen Lei, Li Li, Matt Pepper, Carol Roneker, Marko Vatamaniuk, Xi Yan

Science Nation - Sounds of Survival

submitted by: nsf

They are quiet as church mice ... or are they? See how eavesdropping on mice provides clues about how humans process sound.

The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase

submitted by: tracyanthony
Amino acid starvation by asparaginase (ASNase) enhances phosphorylation of eIF2 by general control nonderepressible 2 (GCN2) kinase, leading to reduced global mRNA translation rates. This conserves energy and allows cells time to reprogram stress-related gene expression to alleviate cell injury. This study addressed the importance of GCN2 for the immune system to adapt to amino acid starvation by ASNase. GCN2+/+ and GCN2-/- mice were injected once daily with ASNase or saline for up to 7 d....
Authors: Carla Aldrich, Ronald Wek, Rachel Reinert, Judy Cundiff, Piyawan Bunpo, Tracy Anthony

A method for reduction of anesthetic waste gases produced by rodent induction chambers

submitted by: jhlvt

Reducing waste gas exposure produced by induction chambers

Rabbit Models for Alzheimer's Disease

submitted by: alex01

Diana Woodruff-Pak (Temple University, Philadelphia, PA) used cholesterol-fed rabbits as a model of AD for evaluation of currently available and potential anti-Alzheimer drugs. These animals developed typical Alzheimer pathology, including behavioral changes and deposition of ß-amyloid and even
tau. Galantamine and donepezil partially protected animals from Alzheimer symptomatology.

Dendrites of rod bipolar cells sprout in normal aging retina

submitted by: Liets
The aging nervous system is known to manifest a variety of degenerative and regressive events. Here we report the unexpected growth of dendrites in the retinas of normal old mice. The dendrites of many rod bipolar cells in aging mice were observed to extend well beyond their normal strata within the outer plexiform layer to innervate the outer nuclear layer where they appeared to form contacts with the spherules of rod photoreceptors. Such dendritic sprouting increased with age and was...
Authors: Lauren c. Liets, Kasra Eliasieh, Deborah a. van der List, Leo m. Chalupa